HPV genotyping and risk factors for anal high-risk HPV infection in men who have sex with men from Toronto, Canada

被引：11

作者：

Choi, Yoojin ^{[1
]}

Loutfy, Mona ^{[2
,3
,4
]}

Remis, Robert S. ^{[2
]}

Liu, Juan ^{[5
]}

Rebbapragada, Anuradha ^{[6
]}

Huibner, Sanja ^{[7
]}

Brunetta, Jason ^{[3
]}

Smith, Graham ^{[3
]}

Reko, Tatjana ^{[8
]}

Halpenny, Roberta ^{[3
]}

Kaul, Rupert ^{[1
,7
,9
]}

Grennan, Troy ^{[10
,11
,12
]}

机构：

[1] Univ Toronto, Dept Immunol, Toronto, ON, Canada

[2] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada

[3] Maple Leaf Med Clin, Toronto, ON, Canada

[4] Womens Coll Hosp, Womens Coll Res Inst, Toronto, ON, Canada

[5] Publ Hlth Ontario, Publ Hlth Lab Toronto, Toronto, ON, Canada

[6] Canada HealthLabs, Toronto, ON, Canada

[7] Univ Toronto, Dept Med, Toronto, ON, Canada

[8] GlaxoSmithKline, Mississauga, ON, Canada

[9] Univ Hlth Network, Dept Med, Toronto, ON, Canada

[10] BC Ctr Dis Control, Vancouver, BC, Canada

[11] Univ British Columbia, Dept Med, Vancouver, BC, Canada

[12] St Pauls Hosp, Vancouver, BC, Canada

来源：

SCIENTIFIC REPORTS | 2021年 / 11卷 / 01期

基金：

加拿大健康研究院;

关键词：

HUMAN-PAPILLOMAVIRUS INFECTION; HIV-UNINFECTED MEN; PREVALENCE; PERSISTENCE; VACCINE; CANCER; PENILE; ANUS; GAY;

D O I：

10.1038/s41598-021-84079-y

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Men who have sex with men (MSM) are disproportionately affected by anal cancer, predominantly caused by high-risk (HR) human papillomavirus (HPV) infection. Currently, the nonavalent HPV vaccine provides coverage against nine HPV genotypes, including seven HR-HPV genotypes. Here, we characterize anal HR-HPV genotype distribution and associated risk factors in MSM from Toronto, Canada recruited between September 2010 and June 2012. Wilcoxon-Mann-Whitney test was used for continuous variables, Chi-square test was performed for categorical variables, and a multivariable model using logistic regression was created to assess for correlates of anal HR-HPV infection. A total of 442 MSM were recruited, with a median age of 45 (IQR 38-50) and an overall HPV prevalence of 82%. The prevalence of any HR-HPV infection was 65.3% and 50.7% in the HIV-positive and HIV-negative MSM, respectively. No participant tested positive for all genotypes covered by the nonavalent vaccine. HIV status (aOR 1.806; 95% CI 1.159-2.816), smoking (aOR 2.176; 95% CI 1.285-3.685) and the number of lifetime sexual partners (aOR 2.466; 95% CI 1.092-5.567) were independent risk factors for anal HR-HPV infection. Our findings will be useful to inform HPV vaccine rollout and HPV prevention strategies in Canadian MSM.

引用

页数：10

共 39 条

[1] Natural Acquired Immunity Against Subsequent Genital Human Papillomavirus Infection: A Systematic Review and Meta-analysis [J].