Multifaceted Roles of Long Non-coding RNAs in Head and Neck Cancer

被引：1

作者：

Duncan, Leslie ^{[1
,2
]}

Shay, Chloe ^{[3
]}

Teng, Yong ^{[1
,4
]}

机构：

[1] Augusta Univ, Dent Coll Georgia, Dept Oral Biol & Diagnost Sci, Augusta, GA 30912 USA

[2] Augusta Univ, Coll Sci & Math, Dept Biol, Augusta, GA USA

[3] Emory Univ, Dept Pediat, Emory Childrens Ctr, Atlanta, GA 30322 USA

[4] Augusta Univ, Med Coll Georgia, Georgia Canc Ctr, Augusta, GA 30912 USA

来源：

REVIEWS ON NEW DRUG TARGETS IN AGE-RELATED DISORDERS, PT II | 2021年 / 1286卷

关键词：

lncRNA; Roles and functions; Head and neck cancer; SQUAMOUS-CELL CARCINOMA; EPITHELIAL-MESENCHYMAL TRANSITION; MOLECULAR-MECHANISMS; METASTASIS; HOTAIR; IDENTIFICATION; SIGNATURE; EMT; BIOMARKERS; EVOLUTION;

D O I：

10.1007/978-3-030-55035-6_7

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The majority of RNA transcripts are non-coding RNA (ncRNA) transcripts with lengths exceeding 200 nucleotides that are not translated into protein. Unlike microRNAs (miRNAs), long ncRNAs (lncRNAs) are not confined to a single mechanism of action but have a large and diverse role in biological processes as they can function as transcription regulators, decoys, scaffolds, and enhancer RNAs. Currently, many lncRNA molecules are under investigation for their role in tumorigenesis, metastasis, and prognosis in different types of cancer. This review not only summarizes the characteristics and functions of lncRNAs but also discusses the therapeutic implications and applications of lncRNAs with roles associated with head and neck cancer. Our aim is to pinpoint the potential way to perturb specific lncRNAs for future therapeutic use.

引用

页码：107 / 114

页数：8

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