Susceptibility to Miltefosine in Brazilian Clinical Isolates of Leishmania (Viannia) braziliensis

被引：17

作者：

Espada, Caroline R. ^{[1
]}

Ribeiro-Dias, Fatima ^{[2
]}

Dorta, Miriam L. ^{[2
]}

de Araujo Pereira, Ledice Inacia ^{[2
]}

de Carvalho, Edgar M. ^{[3
,4
]}

Machado, Paulo R. ^{[3
]}

Schriefer, Albert ^{[3
]}

Yokoyama-Yasunaka, Jenicer K. U. ^{[1
]}

Coelho, Adriano C. ^{[1
,5
]}

Uliana, Silvia R. B. ^{[1
]}

机构：

[1] Univ Sao Paulo, Inst Ciencias Biomed, Dept Parasitol, Lab Leishmanioses, Sao Paulo, Brazil

[2] Univ Fed Goias, Inst Patol Trop & Saude Publ, Lab Imunobiol Leishmanioses, Goiania, Go, Brazil

[3] Univ Fed Bahia, Serv Imunol, Fac Med, Salvador, BA, Brazil

[4] Fiocruz Bahia, Ctr Pesquisas Goncalo Moniz, Salvador, BA, Brazil

[5] Univ Estadual Campinas, Inst Biol, Dept Biol Anim, Campinas, SP, Brazil

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2017年 / 96卷 / 03期

基金：

巴西圣保罗研究基金会;

关键词：

INDIAN VISCERAL LEISHMANIASIS; WORLD CUTANEOUS LEISHMANIASIS; IN-VITRO SUSCEPTIBILITY; MEGLUMINE ANTIMONIATE; DERMAL LEISHMANIASIS; DRUG SUSCEPTIBILITY; AMPHOTERICIN-B; SENSITIVITY; DONOVANI; TRIAL;

D O I：

10.4269/ajtmh.16-0811

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Leishmania (Viannia) braziliensis is the main causative species of tegumentary leishmaniasis in Brazil. In this study, we evaluated the susceptibility of 16 clinical isolates of L. (V.) braziliensis from different regions of Brazil to miltefosine in vitro. Half-maximal inhibitory concentrations of miltefosine varied from 22.9 to 144.2 mu M against promastigotes and from 0.3 to 4.2 mu M against intracellular amastigotes. No significant differences were found between isolates of different geographical origins. A clear correlation between the EC50 against promastigotes and amastigotes within each isolate was found. These findings contribute to the evaluation of miltefosine's potential and limitations for the treatment of tegumentary leishmaniasis in Brazil.

引用

页码：656 / 659

页数：4

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