Synthesis of triple helix forming oligonucleotides with a phenanthroline moiety into the 3′-3′ inversion site of polarity

被引：0

作者：

Esposito, V ^{[1
]}

Galeone, A ^{[1
]}

Mayol, L ^{[1
]}

Oliviero, G ^{[1
]}

Randazzo, A ^{[1
]}

Varra, M ^{[1
]}

机构：

[1] Univ Naples Federico II, Fac Farm, Dipartimento Chim Sostanze Naturali, I-80131 Naples, Italy

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2002年 / 2002卷 / 24期

关键词：

TFO; antigene oligonucleotides; phenanthrolines;

D O I：

10.1002/1099-0690(200212)2002:24<4228::AID-EJOC4228>3.0.CO;2-N

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A protocol for the synthesis of triplex forming oligonucleotides containing a chelating molecule in the 3'-3' inversion site of polarity is reported. A number of 16-mers have been synthesized and UV spectroscopy employed to evaluate the stability of their triple helix complexes with the pertinent double-strand oligonucleotide targets. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2002).

引用

页码：4228 / 4233

页数：6

共 43 条

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