Space flight-associated neuro-ocular syndrome (SANS)

被引:124
作者
Lee, Andrew G. [1 ,2 ,3 ,4 ,5 ,6 ,7 ,8 ]
Mader, Thomas H. [9 ]
Gibson, C. Robert [10 ]
Brunstetter, Tyson J. [11 ]
Tarver, William J. [12 ]
机构
[1] Houston Methodist Hosp, Dept Ophthalmol, Houston, TX 77030 USA
[2] Baylor Coll Med, Houston, TX 77030 USA
[3] Weill Cornell Med Coll, Dept Ophthalmol, New York, NY 10065 USA
[4] Weill Cornell Med Coll, Dept Neurol, New York, NY 10065 USA
[5] Weill Cornell Med Coll, Dept Neurosurg, New York, NY 10065 USA
[6] Univ Texas Med Branch, Dept Ophthalmol, Galveston, TX 77555 USA
[7] Univ Iowa Hosp & Clin, Dept Ophthalmol, Iowa City, IA 52242 USA
[8] UT MD Anderson Canc Ctr Houston, Houston, TX 77030 USA
[9] US Army, Cooper Landing, AK USA
[10] Coastal Eye Associates, Webster, TX USA
[11] NASA, US Navy, Johnson Space Ctr, Houston, TX USA
[12] NASA, Clin Serv, Johnson Space Ctr, Houston, TX USA
关键词
HEAD-DOWN TILT; CEREBROSPINAL-FLUID OUTFLOW; CHOROIDAL FOLDS; INTRACRANIAL HYPERTENSION; OPTIC-NERVE; INTRAOCULAR-PRESSURE; ACQUIRED HYPEROPIA; PAPILLEDEMA; ASTRONAUTS; MICROGRAVITY;
D O I
10.1038/s41433-018-0070-y
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Interesting novel and somewhat perplexing physiologic and pathologic neuro-ocular findings have been documented in astronauts during and after long duration space flight (LDSF). These findings collectively have been termed the "space flight-associated neuro-ocular syndrome" (SANS). The National Aeronautics and Space Administration (NASA) in the United States has meticulously and prospectively documented the clinical, ultrasound, optical coherence tomography imaging, and radiographic findings of SANS including unilateral and bilateral optic disc edema, globe flattening, choroidal and retinal folds, hyperopic refractive error shifts, and nerve fiber layer infarcts (i.e., cotton wool spots). NASA and collaborating researchers continue to study SANS in preparation for future manned missions to space, including continued trips to the ISS, a return to the moon, or perhaps new voyages to the asteroid belt, or the planet, Mars.
引用
收藏
页码:1164 / 1167
页数:4
相关论文
共 50 条
[41]   Space Flight-Associated Neuroocular Syndrome, Idiopathic Intracranial Hypertension, and Pseudotumor Cerebri: Phenotypic Descriptions, Pathogenesis, and Hydrodynamics [J].
Kesserwani, Hassan .
CUREUS JOURNAL OF MEDICAL SCIENCE, 2021, 13 (03)
[42]   Reducing intracranial pressure by reducing central venous pressure: assessment of potential countermeasures to spaceflight-associated neuro-ocular syndrome [J].
Hansen, Alexander B. ;
Lawley, Justin S. ;
Rickards, Caroline A. ;
Howden, Erin J. ;
Sarma, Satyam ;
Cornwell, William K., III ;
Amin, Sachin B. ;
Mugele, Hendrik ;
Marume, Kyohei ;
Possnig, Carmen ;
Whitworth, Louis A. ;
Williams, Michael A. ;
Levine, Benjamin D. .
JOURNAL OF APPLIED PHYSIOLOGY, 2021, 130 (02) :283-289
[43]   Hypothesis on the outflow of optic nerve cerebrospinal fluid in spaceflight associated neuro ocular syndrome [J].
Hu, Yuwei ;
Lin, Yuanxi ;
Cheng, Lu ;
Xu, Yang ;
Zhang, Jian ;
Zheng, Zheng ;
Wang, Huan ;
Yan, Min ;
Chen, Hui .
NPJ MICROGRAVITY, 2024, 10 (01)
[44]   Effect of Nightly Lower Body Negative Pressure on Choroid Engorgement in a Model of Spaceflight-Associated Neuro-ocular Syndrome A Randomized Crossover Trial [J].
Hearon, Christopher M., Jr. ;
Dias, Katrin A. ;
Babu, Gautam ;
Marshall, John E. T. ;
Leidner, James ;
Peters, Kirsten ;
Silva, Erika ;
MacNamara, James P. ;
Campain, Joseph ;
Levine, Benjamin D. .
JAMA OPHTHALMOLOGY, 2022, 140 (01) :59-65
[45]   A potential compensatory mechanism for spaceflight associated neuro-ocular changes from microgravity: current understanding and future directions [J].
Soares, Benjamin ;
Ong, Joshua ;
Osteicoechea, Daniela ;
Kadipasaoglu, Cihan Mehmet ;
Waisberg, Ethan ;
Sarker, Prithul ;
Zaman, Nasif ;
Tavakkoli, Alireza ;
Vizzeri, Gianmarco ;
Lee, Andrew G. .
EYE, 2024, 38 (09) :1605-1607
[46]   Mechanical countermeasures for spaceflight-associated neuro-ocular syndrome during 30-days of head down tilt bed rest: design, implementation, and tolerability [J].
Moestl, Stefan ;
De Boni, Laura ;
Hoenemann, Jan-Niklas ;
Kramer, Tilmann ;
Schmitz, Jan ;
Pesta, Dominik ;
Frett, Timo ;
Bohmeier, Maria ;
Frings-Meuthen, Petra ;
Ewald, Ann Charlotte ;
Nitsche, Andrea ;
Loehr, Patricia ;
Noppe, Alexandra ;
Klischies, Nicolas ;
Huang, Alex S. ;
Laurie, Steven S. ;
Marshall-Goebel, Karina ;
Macias, Brandon R. ;
Tank, Jens ;
Jordan, Jens ;
Mulder, Edwin .
FRONTIERS IN PHYSIOLOGY, 2025, 16
[47]   Shared mechanisms in neuromyelitis optica spectrum disorder and spaceflight-associated neuro-ocular syndrome: Insights into central nervous system fluid dynamics, glymphatic function, and astrocyte dysregulation [J].
Paladugu, Phani ;
Kumar, Rahul ;
Sporn, Kyle ;
Ong, Joshua ;
Song, Amy ;
Sekhar, Tejas ;
Gowda, Chirag ;
Davidoff, Nicole ;
Shin, Samuel ;
Lee, Andrew G. .
LIFE SCIENCES IN SPACE RESEARCH, 2025, 47 :43-56
[48]   Ocular counterrolling induced by centrifugation during orbital space flight [J].
Moore, ST ;
Clément, G ;
Raphan, T ;
Cohen, B .
EXPERIMENTAL BRAIN RESEARCH, 2001, 137 (3-4) :323-335
[49]   Spatial orientation of optokinetic nystagmus and ocular pursuit during orbital space flight [J].
Steven T. Moore ;
Bernard Cohen ;
Theodore Raphan ;
Alain Berthoz ;
Gilles Clément .
Experimental Brain Research, 2005, 160 :38-59
[50]   Spatial orientation of optokinetic nystagmus and ocular pursuit during orbital space flight [J].
Moore, ST ;
Cohen, B ;
Raphan, T ;
Berthoz, A ;
Clément, G .
EXPERIMENTAL BRAIN RESEARCH, 2005, 160 (01) :38-59