Space flight-associated neuro-ocular syndrome (SANS)

被引：124

作者：

Lee, Andrew G. ^{[1
,2
,3
,4
,5
,6
,7
,8
]}

Mader, Thomas H. ^{[9
]}

Gibson, C. Robert ^{[10
]}

Brunstetter, Tyson J. ^{[11
]}

Tarver, William J. ^{[12
]}

机构：

[1] Houston Methodist Hosp, Dept Ophthalmol, Houston, TX 77030 USA

[2] Baylor Coll Med, Houston, TX 77030 USA

[3] Weill Cornell Med Coll, Dept Ophthalmol, New York, NY 10065 USA

[4] Weill Cornell Med Coll, Dept Neurol, New York, NY 10065 USA

[5] Weill Cornell Med Coll, Dept Neurosurg, New York, NY 10065 USA

[6] Univ Texas Med Branch, Dept Ophthalmol, Galveston, TX 77555 USA

[7] Univ Iowa Hosp & Clin, Dept Ophthalmol, Iowa City, IA 52242 USA

[8] UT MD Anderson Canc Ctr Houston, Houston, TX 77030 USA

[9] US Army, Cooper Landing, AK USA

[10] Coastal Eye Associates, Webster, TX USA

[11] NASA, US Navy, Johnson Space Ctr, Houston, TX USA

[12] NASA, Clin Serv, Johnson Space Ctr, Houston, TX USA

来源：

EYE | 2018年 / 32卷 / 07期

关键词：

HEAD-DOWN TILT; CEREBROSPINAL-FLUID OUTFLOW; CHOROIDAL FOLDS; INTRACRANIAL HYPERTENSION; OPTIC-NERVE; INTRAOCULAR-PRESSURE; ACQUIRED HYPEROPIA; PAPILLEDEMA; ASTRONAUTS; MICROGRAVITY;

D O I：

10.1038/s41433-018-0070-y

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Interesting novel and somewhat perplexing physiologic and pathologic neuro-ocular findings have been documented in astronauts during and after long duration space flight (LDSF). These findings collectively have been termed the "space flight-associated neuro-ocular syndrome" (SANS). The National Aeronautics and Space Administration (NASA) in the United States has meticulously and prospectively documented the clinical, ultrasound, optical coherence tomography imaging, and radiographic findings of SANS including unilateral and bilateral optic disc edema, globe flattening, choroidal and retinal folds, hyperopic refractive error shifts, and nerve fiber layer infarcts (i.e., cotton wool spots). NASA and collaborating researchers continue to study SANS in preparation for future manned missions to space, including continued trips to the ISS, a return to the moon, or perhaps new voyages to the asteroid belt, or the planet, Mars.

引用

页码：1164 / 1167

页数：4