Increased platelet aggregation induced activeiting by anti-glycoprotein IIb/IIIa antibody in patients with acute coronary syndrome

被引:0
|
作者
Voskoboy, IV [1 ]
Mazurov, AV
机构
[1] Saratov State Med Univ, Saratov, Russia
[2] Russian Cardiol Res Complex, Moscow 121552, Russia
关键词
acute coronary syndrome; platelets; aggregation; glycoprotein IIb/IIIa;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Interaction of glycoprotein (GP) IIb/IIIa with fibrinogen is the final and key reaction in platelet aggregation. In order to evaluate GP IIb-IIIa functional activity in patients with acute coronary syndrome (ACS) we measured platelet aggregation induced by monoclonal antibody CRC54 which is directed against GP IIb/IIIa and is able to stimulate its binding with fibrinogen and subsequent aggregation. Patients with ACS were divided into 3 groups: (1) with Q-wave myocardial infarction (MI), (2) with non Q-wave MI and with unstable angina. Patients with stable angina (SA) and healthy donors formed 2 comparison groups. The level and rate of CRC54-induced aggregation measured both in the absence and in the presence of prostaglandin E-1 (PGE(1)), the inhibitor of platelet activation, in all groups of patients with ACS were greater than or equal to 1.5 times higher than in SA patients and healthy donors. Observed differences in the parameters of CRC54-induced aggregation at least in the presence of PGE(1) could be caused only by increased GP IIb/IIIa fibrinogen binding ability in ACS patients, but not by differences in the level of platelet activation. In all groups of patients with ACS, but not in SA patients and healthy donors, strong correlation (r=-0.5-0.7) was observed between increased parameters of ADP-induced aggregation and aggregation stimulated by CRC54 in the presence of PGE(1). The data obtained indicated that increased of platelet aggregating capacity in ACS might be caused by changes of GP IIb/IIIa functional characteristics and not by enhancement of platelet sensitivity towards physiological agonists including ADP.
引用
收藏
页码:64 / 70
页数:9
相关论文
共 50 条
  • [31] PLATELET ACTIVATION INDUCED BY A MONOCLONAL-ANTIBODY DIRECTED TO THE PLATELET GLYCOPROTEIN IIB/IIIA COMPLEX
    MODDERMAN, PW
    HUISMAN, JG
    VANMOURIK, JA
    VONDEMBORNE, AECK
    BRITISH JOURNAL OF HAEMATOLOGY, 1987, 66 (03) : 419 - 420
  • [33] Role of oral blockade of platelet glycoprotein IIb/IIIa on neutrophil activation in patients with acute coronary syndromes
    Serrano, CV
    Nicolau, JC
    Venturinelli, M
    Baracioli, LM
    Anders, RJ
    Cannon, CP
    Ramires, JAF
    CARDIOVASCULAR DRUGS AND THERAPY, 2003, 17 (02) : 129 - 132
  • [34] Glycoprotein IIb/IIIa receptor inhibitors in percutaneous coronary intervention and acute coronary syndrome
    Crouch, MA
    Nappi, JM
    Cheang, KI
    ANNALS OF PHARMACOTHERAPY, 2003, 37 (06) : 860 - 875
  • [35] Role of Oral Blockade of Platelet Glycoprotein IIb/IIIa on Neutrophil Activation in Patients with Acute Coronary Syndromes
    Carlos V. Serrano
    José C. Nicolau
    Margareth Venturinelli
    Luciano M. Baracioli
    Robert J. Anders
    Christopher P. Cannon
    José A. F. Ramires
    Cardiovascular Drugs and Therapy, 2003, 17 : 129 - 132
  • [36] PLATELET GLYCOPROTEIN IIB-IIIA AND SIZE ARE INCREASED IN ACUTE MYOCARDIAL-INFARCTION
    GILES, H
    SMITH, REA
    MARTIN, JF
    EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 1994, 24 (01) : 69 - 72
  • [37] Role of oral blockade of platelet glycoprotein IIb/IIIa on neutrophil-platelet interactions in patients with acute coronary syndromes
    Serrano, CV
    Venturinelli, M
    Ramires, JAF
    Cannon, CP
    Nicolau, JC
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2000, 35 (02) : 343A - 343A
  • [38] BLEEDING COMPLICATIONS WITH THE CHIMERIC ANTIBODY TO PLATELET GLYCOPROTEIN IIB/IIIA INTEGRIN IN PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION
    AGUIRRE, FV
    TOPOL, EJ
    FERGUSON, JJ
    ANDERSON, K
    BLANKENSHIP, JC
    HEUSER, RR
    SIGMON, K
    TAYLOR, M
    GOTTLIEB, R
    HANOVICH, G
    ROSENBERG, M
    DONOHUE, TJ
    WEISMAN, HF
    CALIFF, RM
    CIRCULATION, 1995, 91 (12) : 2882 - 2890
  • [39] INCREASED SURFACE EXPRESSION OF THE MEMBRANE GLYCOPROTEIN IIB/IIIA COMPLEX INDUCED BY PLATELET ACTIVATION - RELATIONSHIP TO THE BINDING OF FIBRINOGEN AND PLATELET-AGGREGATION
    NIIYA, K
    HODSON, E
    BADER, R
    BYERSWARD, V
    KOZIOL, JA
    PLOW, EF
    RUGGERI, ZM
    BLOOD, 1987, 70 (02) : 475 - 483
  • [40] Platelet glycoprotein IIb/IIIa inhibition with coronary stenting for acute myocardial infarction.
    Montalescot, G
    Barragan, P
    Wittenberg, O
    Ecollan, P
    Elhadad, S
    Villain, P
    Boulenc, JM
    Morice, MC
    Maillard, L
    Pansiéri, M
    Choussat, R
    Pinton, P
    NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (25): : 1895 - 1903