Involvement of p38 MAPkinase in attenuation of antinociceptive effect of morphine in diabetic mice

被引：0
|
作者：
Gilhotra, Neeraj
Sharma, Ajay
Singh, Manjeet
Dhingra, Dinesh
机构：
[1] Punjabi Univ, Dept Pharmaceut Sci & Drug Res, Patiala 147002, Punjab, India
[2] Guru Jambheshwar Univ, Dept Pharmaceut Sci, Hisar 125001, Haryana, India
来源：
INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY | 2007年 / 45卷 / 07期
关键词：
antinociception; diabetes; FR-167653; morphine; p38MAPKinase;
D O I：
暂无
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Experimental diabetes induced by streptozotocin (200 mg/kg, ip) markedly decreased the antinociceptive effect of morphine and significantly increased the urinary nitrite concentration. Administration of FR-167653 (a selective p38MAPKinase inhibitor) in a dose of 4 mg/kg improved the antinociceptive effect of morphine and attenuated the increase in urinary nitrite concentration in diabetic mice. It may be concluded that diabetes-induced decrease in antinociceptive effect of morphine may be due to induction of p38 MAPKinase activity.
引用
收藏
页码：654 / 656
页数：3
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