Biological insights into the piericidin family of microbial metabolites

被引：12

作者：

Azad, Sepideh M. ^{[1
]}

Jin, Yu ^{[2
]}

Ser, Hooi-Leng ^{[3
]}

Goh, Bey-Hing ^{[4
]}

Lee, Learn-Han ^{[3
]}

Thawai, Chitti ^{[5
]}

He, Ya-Wen ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, State Key Lab Microbial Metab, Joint Int Res Lab Metab & Dev Sci, Shanghai, Peoples R China

[2] East China Sci & Technol Univ, Sch Biotechnol, Shanghai, Peoples R China

[3] Monash Univ Malaysia, Jeffrey Cheah Sch Med & Hlth Sci, Novel Bacteria & Drug Discovery Res Grp NBDD, Subang Jaya, Selangor, Malaysia

[4] Monash Univ Malaysia, Sch Pharm, Biofunct Mol Exploratory Res Grp BMEX, Subang Jaya, Selangor, Malaysia

[5] King Mongkuts Inst Technol Ladkrabang, Fac Sci, Dept Biol, Bangkok, Thailand

来源：

JOURNAL OF APPLIED MICROBIOLOGY | 2022年 / 132卷 / 02期

关键词：

antimicrobial activity; anti-tumour activity; biosynthetic pathway; insecticidal activity; Piericidin; Streptomyces; PHYSIOLOGICAL ACTIVITIES; STRUCTURE ELUCIDATION; DRUG-RESISTANCE; STREPTOMYCES SP; ANTIBIOTICS; SUPEROXIDE; INHIBITORS; GLUCOPIERICIDIN; CELLS; SITE;

D O I：

10.1111/jam.15222

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Extensively produced by members of the genus Streptomyces, piericidins are a large family of microbial metabolites, which consist of main skeleton of 4-pyridinol with methylated polyketide side chain. Nonetheless, these metabolites show differences in their bioactive potentials against micro-organisms, insects and tumour cells. Due to its close structural similarity with coenzyme Q, piericidins also possess an inhibitory activity against NADH dehydrogenase as well as Photosystem II. This review studied the latest research progress of piericidins, covering the chemical structure and physical properties of newly identified members, bioactivities, biosynthetic pathway with gene clusters and future prospect. With the increasing incidence of drug-resistant human pathogen strains and cancers, this review aimed to provide clues for the development of either new potential antibiotics or anti-tumour agents.

引用

页码：772 / 784

页数：13

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