Binding of [1-C-14]methyl isocyanate to erythrocyte membrane proteins

被引：0

作者：

Bhattacharya, BK

Sharma, SK

Jaiswal, DK

机构：

[1] Department of Biochemistry, Def. Res./Devmt. Establishment

来源：

JOURNAL OF APPLIED TOXICOLOGY | 1996年 / 16卷 / 02期

关键词：

methyl isocyanate; erythrocyte membrane; band III; sulphydryl group;

D O I：

10.1002/(SICI)1099-1263(199603)16:2<137::AID-JAT317>3.0.CO;2-E

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

We describe the interaction of methyl isocyanate with reactive sulphydryl groups of rat erythrocyte membrane proteins. Intraperitoneal administration, as well as in vitro incubation of methyl isocyanate, caused a significant reduction in the free sulphydryl content of erythrocyte membrane proteins. [1-C-14]Methyl isocyanate was specifically bound to band III of the erythrocyte membrane and caused the breakdown of band III proteins.

引用

页码：137 / 138

页数：2

共 6 条

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