Magneto-immunoassay of cancer biomarkers: Recent progress and challenges in biomedical analysis

被引:19
作者
Kavetskyy, Taras [1 ,2 ]
Alipour, Mahdieh [3 ]
Smutok, Oleh [4 ,5 ]
Mushynska, Oksana [1 ]
Kiv, Arnold [6 ]
Fink, Dietmar [7 ,8 ]
Farshchi, Fatemeh [9 ]
Ahmadian, Elham [9 ]
Hasanzadeh, Mohammad [10 ]
机构
[1] Drohobych Ivan Franko State Pedag Univ, Drogobych 82100, Ukraine
[2] John Paul II Catholic Univ Lublin, Lublin 20950, Poland
[3] Tabriz Univ Med Sci, Dent & Periodontal Res Ctr, Tabriz, Iran
[4] Clarkson Univ, Dept Chem & Biomol Sci, New York, NY 13699 USA
[5] Natl Acad Sci Ukraine, Inst Cell Biol, Lvov 79005, Ukraine
[6] South Ukrainian KD Ushynsky Natl Pedag Univ, Odessa 65020, Ukraine
[7] Univ Autonoma Metropolitana Iztapalapa, POB 55-534, Mexico City 09340, DF, Mexico
[8] ASCR, Inst Nucl Phys, Rez 25068, Czech Republic
[9] Tabriz Univ Med Sci, Pharmaceut Anal Res Ctr, Tabriz, Iran
[10] Tabriz Univ Med Sci, Kidney Res Ctr, Tabriz, Iran
基金
新加坡国家研究基金会;
关键词
Cancer; Nanobiomedicine; Biomedical analysis; Biotechnology; Magnetic nanomaterials; Electrochemistry; Optical biosensors; IRON-OXIDE NANOPARTICLES; ELECTROCHEMICAL IMMUNOSENSOR; LUNG-CANCER; ELECTROCHEMILUMINESCENCE IMMUNOSENSOR; CARCINOEMBRYONIC ANTIGEN; IMMUNOMAGNETIC DETECTION; GRAPHENE OXIDE; STRATEGIES; BIOSENSORS; SYSTEMS;
D O I
10.1016/j.microc.2021.106320
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Ultrasensitive biomarker sensing has been used to develop novel strategies in detecting early stage cancer. Due to their unique characteristics, ie, ease of synthesis, conductivity and bio-compatibility, iron magnetic nanoparticles (MNPs) are exceptional nanomaterial in theragnostics. The current review focuses the critical role of iron MNPs in the development of several immunoassay technologies including electrochemical, electrochemiluminescent, photoelectrochemical, optical and microfluidic biosensors. Type and composition of magnetic particles, detection methods, relative specificity and sensitivity is discussed. Advantages and limitations of various strategies for label-free immunosensing of cancer biomarkers are explored.
引用
收藏
页数:13
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