Small molecule inhibitors of the XIAP protein-protein interaction

被引：12
|
作者：
Rajapakse, Hemaka A. [1 ]
机构：
[1] Merck Res Labs, Dept Med Chem, West Point, PA 19486 USA
来源：
CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2007年 / 7卷 / 10期
关键词：
XIAP; small molecule inhibitor; apoptosis; BIR; 2; 3; Smac;
D O I：
10.2174/156802607780906816
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The X-linked inhibitor of apoptosis proteins (XIAP) is thought to play a key role in the unchecked proliferation of cancer cells by interfering with the signaling cascade leading to cell death. The structure and mechanism of XIAP has been widely investigated and characterized over the past few years, to the point where this may be the best understood apoptosis protein inhibitor. As a result, XIAP is viewed as an attractive target for the treatment of cancer. To date, several research groups have reported on the discovery of small molecule inhibitors of this protein. This review focuses on the discovery and optimization of these leads.
引用
收藏
页码：966 / 971
页数：6
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