Total Synthesis of 6-Hydroxymetatacarboline-D Discovered from Mycena metata via the Pictet-Spengler Reaction Followed by the Horner-Wadsworth-Emmons Reaction

被引：2

作者：

Kumar, Deepak ^{[1
,2
,3
]}

Vaya, Dipti ^{[1
]}

Chundawat, Tejpal Singh ^{[2
]}

机构：

[1] Amity Univ, Dept Chem, Gurgaon 122017, Haryana Am, India

[2] North Cap Univ, Dept Appl Sci, Gurgaon 122017, Haryana, India

[3] Jubilant Biosys Ltd, R&D Ctr, Noida 201301, UP, India

来源：

ACS OMEGA | 2021年 / 6卷 / 13期

关键词：

BETA-CARBOLINE ALKALOIDS; NATURAL-PRODUCTS; DERIVATIVES; DIVERSITY; SCAFFOLD; DESIGN; MILD;

D O I：

10.1021/acsomega.0c06202

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Total synthesis of a new beta-carboline alkaloid, 6-hydroxymetatacarboline-D, which was isolated from fruiting bodies of Mycena metata was accomplished in 14 steps. The synthetic strategy features the Pictet-Spengler reaction to construct the tricyclic core followed by amide coupling and the Horner-Wadsworth-Emmons reaction.

引用

页码：8933 / 8941

页数：9

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