Neuropsychiatric Symptoms and Alzheimer's Disease Biomarkers Predict Driving Decline: Brief Report

被引：13

作者：

Babulal, Ganesh M. ^{[1
,2
]}

Stout, Sarah H. ^{[1
,2
]}

Head, Denise ^{[1
,4
,5
]}

Holtzman, David M. ^{[1
,2
,3
]}

Fagan, Anne M. ^{[1
,2
,3
]}

Morris, John C. ^{[1
,2
,3
,6
,7
,8
]}

Roe, Catherine M. ^{[1
,2
]}

机构：

[1] Washington Univ, Sch Med, Knight Alzheimers Dis Res Ctr, St Louis, MO USA

[2] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, Hope Ctr Neurol Disorders, St Louis, MO USA

[4] Washington Univ, Sch Med, Dept Psychol & Brain Sci, St Louis, MO USA

[5] Washington Univ, Sch Med, Dept Radiol, St Louis, MO 63110 USA

[6] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO USA

[7] Washington Univ, Sch Med, Dept Phys Therapy, St Louis, MO USA

[8] Washington Univ, Sch Med, Dept Occupat Therapy, St Louis, MO USA

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2017年 / 58卷 / 03期

关键词：

Alzheimer's disease; cerebrospinal fluid; depression; neuropsychology; noncognitive outcomes; preclinical; OLDER-ADULTS; MOOD STATES; DEMENTIA; PERFORMANCE; MILD; FORM;

D O I：

10.3233/JAD-170067

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined whether neuropsychiatric symptoms (NPS) interact with cerebrospinal fluid (CSF) biomarkers (amyloid-beta(42) [A beta(42)], tau, phosphorylated tau(181) [ptau(181)], tau/A beta(42), and ptau(181)/A beta(42)) of Alzheimer's disease pathology to predict driving decline among cognitively-normal older adults (N= 116) aged >= 65. Cox proportional hazards models examined time to receiving a rating of marginal or fail on the driving test. Age, education, and gender were adjusted in the models. Participants with more abnormal CSF (A beta(42), tau/A beta(42), ptau(181)/A beta(42)) and NPS were faster to receive a marginal/fail on the road test compared to those without NPS. NPS interact with abnormal CSF biomarkers to impact driving performance among cognitively-normal older adults.

引用

页码：675 / 680

页数：6

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