Neuropsychiatric Symptoms and Alzheimer's Disease Biomarkers Predict Driving Decline: Brief Report

被引：13
作者：
Babulal, Ganesh M. [1 ,2 ]
Stout, Sarah H. [1 ,2 ]
Head, Denise [1 ,4 ,5 ]
Holtzman, David M. [1 ,2 ,3 ]
Fagan, Anne M. [1 ,2 ,3 ]
Morris, John C. [1 ,2 ,3 ,6 ,7 ,8 ]
Roe, Catherine M. [1 ,2 ]
机构：
[1] Washington Univ, Sch Med, Knight Alzheimers Dis Res Ctr, St Louis, MO USA
[2] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA
[3] Washington Univ, Sch Med, Hope Ctr Neurol Disorders, St Louis, MO USA
[4] Washington Univ, Sch Med, Dept Psychol & Brain Sci, St Louis, MO USA
[5] Washington Univ, Sch Med, Dept Radiol, St Louis, MO 63110 USA
[6] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO USA
[7] Washington Univ, Sch Med, Dept Phys Therapy, St Louis, MO USA
[8] Washington Univ, Sch Med, Dept Occupat Therapy, St Louis, MO USA
来源：
JOURNAL OF ALZHEIMERS DISEASE | 2017年 / 58卷 / 03期
关键词：
Alzheimer's disease; cerebrospinal fluid; depression; neuropsychology; noncognitive outcomes; preclinical; OLDER-ADULTS; MOOD STATES; DEMENTIA; PERFORMANCE; MILD; FORM;
D O I：
10.3233/JAD-170067
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We examined whether neuropsychiatric symptoms (NPS) interact with cerebrospinal fluid (CSF) biomarkers (amyloid-beta(42) [A beta(42)], tau, phosphorylated tau(181) [ptau(181)], tau/A beta(42), and ptau(181)/A beta(42)) of Alzheimer's disease pathology to predict driving decline among cognitively-normal older adults (N= 116) aged >= 65. Cox proportional hazards models examined time to receiving a rating of marginal or fail on the driving test. Age, education, and gender were adjusted in the models. Participants with more abnormal CSF (A beta(42), tau/A beta(42), ptau(181)/A beta(42)) and NPS were faster to receive a marginal/fail on the road test compared to those without NPS. NPS interact with abnormal CSF biomarkers to impact driving performance among cognitively-normal older adults.
引用
收藏
页码：675 / 680
页数：6
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