Highly enantioselective synthesis of a chiral 3-quinolylalkanol by an asymmetric autocatalytic reaction

被引：58
|
作者：
Shibata, T [1 ]
Choji, K [1 ]
Morioka, H [1 ]
Hayase, T [1 ]
Soai, K [1 ]
机构：
[1] SCI UNIV TOKYO,FAC SCI,DEPT APPL CHEM,SHINJUKU KU,TOKYO 162,JAPAN
来源：
CHEMICAL COMMUNICATIONS | 1996年 / 06期
关键词：
D O I：
10.1039/cc9960000751
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A catalytic amount of a chiral zinc alkoxide of 2-methyl-1-(3-quinolyl)propan-1-ol catalyses the enantioselective alkylation of quinoline-3-carbaldehyde by diisopropylzine to afford 2-methyl-1-(3-quinolyl)propan-1-ol with the same configuration in high ee (up to 94%).
引用
收藏
页码：751 / 752
页数：2
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