Highly enantioselective synthesis of a chiral 3-quinolylalkanol by an asymmetric autocatalytic reaction

被引：58

作者：

Shibata, T ^{[1
]}

Choji, K ^{[1
]}

Morioka, H ^{[1
]}

Hayase, T ^{[1
]}

Soai, K ^{[1
]}

机构：

[1] SCI UNIV TOKYO,FAC SCI,DEPT APPL CHEM,SHINJUKU KU,TOKYO 162,JAPAN

来源：

CHEMICAL COMMUNICATIONS | 1996年 / 06期

关键词：

D O I：

10.1039/cc9960000751

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A catalytic amount of a chiral zinc alkoxide of 2-methyl-1-(3-quinolyl)propan-1-ol catalyses the enantioselective alkylation of quinoline-3-carbaldehyde by diisopropylzine to afford 2-methyl-1-(3-quinolyl)propan-1-ol with the same configuration in high ee (up to 94%).

引用

页码：751 / 752

页数：2

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