Study the effect of Vitamin K on intracellular NAD level in yeast by fluorescence spectrum

被引：2

作者：

Chen Yahong

Cai Ruxiu ^{[1
]}

Zhang Ke

机构：

[1] Wuhan Univ, Dept Chem, Wuhan 430072, Peoples R China

[2] Zhoukou Normal Univ, Dept Chem, Zhoukou 466000, Peoples R China

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2007年 / 67卷 / 01期

基金：

中国国家自然科学基金;

关键词：

vitamin K; cellular; NAD level;

D O I：

10.1016/j.saa.2006.07.014

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

s The intracellular NAD level plays a pivotal role in numerous biological processes such as rhythm, senescence, cancer and death. The study of the intracellular NAD level has been one of the "hotspots" in biomedical research. We investigated the effect of Vitamin K on intracellular NAD level in yeast by fluorescence spectrum in this paper. Plasma membrane redox system of yeast was found to be greatly promoted by the addition of Vitamin K-3 or Vitamin K-1. Ferricyanide reduction catalyzed by Vitamin K was accompanied by the decrease in intracellular NADH concentration and the increase in intracellular NAD level of yeast cells. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：235 / 239

页数：5

共 30 条

[1] NAD+-dependent deacetylase Hst1p controls biosynthesis and cellular NAD+ levels in Saccharomyces cerevisiae [J].