Eculizumab and aHUS: to stop or not

被引：18

作者：

Brodsky, Robert A. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Baltimore, MD 21218 USA

来源：

BLOOD | 2021年 / 137卷 / 18期

关键词：

COMPLEMENT INHIBITOR ECULIZUMAB;

D O I：

10.1182/blood.2020010234

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In this issue of Blood, Fakhouri et al(1) provide evidence in a prospective phase 4, multicentric, noncontrolled study that discontinuing eculizumab is safe in most patients with atypical hemolytic uremic syndrome (aHUS) once they achieve complete remission. Risk of relapse was <25% overall, but as high as 50% in patients with a rare variant in at least 1 complement gene.

引用

页码：2419 / 2420

页数：2

共 9 条

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