Lymphatic vascular specification and its modulation during embryonic development

被引:3
作者
Pichol-Thievend, Cathy [1 ]
Hogan, Benjamin M. [1 ]
Francois, Mathias [1 ]
机构
[1] Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia
基金
澳大利亚研究理事会; 英国医学研究理事会;
关键词
Lymphatic endothelial cell; Vascular; Specification; Transcription factors; Signalling pathways; Zebrafish; Mouse; Lymphoedema; GROWTH-FACTOR-C; RECEPTOR COUP-TFII; VEGF-D PROMOTES; ENDOTHELIAL-CELLS; RETINOIC ACID; NEGATIVE REGULATOR; VESSEL DEVELOPMENT; REDUNDANT ROLES; LYMPHANGIOGENESIS; SOX18;
D O I
10.1016/j.mvr.2014.07.011
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Despite its essential roles in development and disease, the lymphatic vascular system has been less studied than the blood vascular network. In recent years, significant advances have been made in understanding the mechanisms that regulate lymphatic vessel formation, both during development and in pathological conditions. Remarkably, lymphatic endothelial cells are specified as a subpopulation of pre-existing venous endothelial cells. Here, we summarize the current knowledge of the transcription factor pathways responsible for lymphatic specification and we also focus on the factors that promote or restrict this event. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码:3 / 9
页数:7
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