Synthesis of polyamines, their derivatives, analogues and conjugates

被引:0
作者
Kuksa, V [1 ]
Buchan, R [1 ]
Lin, PKT [1 ]
机构
[1] Robert Gordon Univ, Sch Appl Sci, Aberdeen AB25 1HG, Scotland
来源
SYNTHESIS-STUTTGART | 2000年 / 09期
关键词
polyamines; analogue; conjugates; synthesis; methodology;
D O I
暂无
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The role of polyamines in biological systems is now well recognised. In this review an introduction to polyamines and their biological significance is first outlined. The main focus of this review is on the chemical strategies used in the synthesis of polyamines, their derivatives, analogues and conjugates. Recent developments in solid phase synthesis of more complex polyamine molecules is also covered.
引用
收藏
页码:1189 / 1207
页数:19
相关论文
共 84 条
  • [1] ALGRANATI ID, 1977, TIBS, P272
  • [2] BACHRACH U, 1989, PHYSL POLYAMINES, V2, P235
  • [3] BASU HS, 1992, FALK SYMP, V62, P35
  • [4] Structural comparison of alkylpolyamine analogues with potent in vitro antitumor or antiparasitic activity
    Bellevue, FH
    Boahbedason, M
    Wu, RH
    Woster, PM
    Casero, RA
    Rattendi, D
    Lane, S
    Bacchi, CJ
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1996, 6 (22) : 2765 - 2770
  • [5] Inverse agonists at the polyamine-sensitive modulatory site of the NMDA receptor:: 50-fold increase in potency by insertion of an aromatic ring into an alkanediamine chain
    Berger, ML
    Schödl, C
    Noe, CR
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1998, 33 (01) : 3 - 14
  • [6] METHODS FOR THE SELECTIVE MODIFICATION OF SPERMIDINE AND ITS HOMOLOGS
    BERGERON, RJ
    [J]. ACCOUNTS OF CHEMICAL RESEARCH, 1986, 19 (04) : 105 - 113
  • [7] ANTIPROLIFERATIVE PROPERTIES OF POLYAMINE ANALOGS - A STRUCTURE-ACTIVITY STUDY
    BERGERON, RJ
    MCMANIS, JS
    LIU, CZ
    FENG, Y
    WEIMAR, WR
    LUCHETTA, GR
    WU, QH
    ORTIZOCASIO, J
    VINSON, JRT
    KRAMER, D
    PORTER, C
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (21) : 3464 - 3476
  • [8] Polyamine analogue regulation of NMDA MK-801 binding: A structure-activity study
    Bergeron, RJ
    Weimar, WR
    Wu, QH
    Feng, Y
    McManis, JS
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (26) : 5257 - 5266
  • [9] A comparison of structure-activity relationships between spermidine and spermine analogue antineoplastics
    Bergeron, RJ
    Feng, Y
    Weimar, WR
    McManis, JS
    Dimova, H
    Porter, C
    Raisler, B
    Phanstiel, O
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1997, 40 (10) : 1475 - 1494
  • [10] ALPHA-(FLUOROMETHYL)DEHYDROORNITHINE AND ALPHA-(FLUOROMETHYL)DEHYDROPUTRESCINE ANALOGS AS IRREVERSIBLE INHIBITORS OF ORNITHINE DECARBOXYLASE
    BEY, P
    GERHART, F
    VANDORSSELAER, V
    DANZIN, C
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1983, 26 (11) : 1551 - 1556