Dose-dependent effects of propofol on expression ICAM-1 in rabbit aorta endothelial cells

被引：0
|
作者：
Ketani, M. Aydin [1 ]
Kanay, Berna Ersoez [2 ]
Ketani, Sennur [3 ]
Unver, Ozkan [4 ]
Kilinc, Mehmet [5 ]
机构：
[1] Dicle Univ, Fac Vet Med, Dept Histol & Embryol, TR-21280 Diyarbakir, Turkey
[2] Dicle Univ, Fac Vet Med, Dept Surg, TR-21280 Diyarbakir, Turkey
[3] Dicle Univ, Fac Educ, Dept Biol Educ, TR-21280 Diyarbakir, Turkey
[4] Dicle Univ, Fac Vet Med, Dept Pathol, TR-21280 Diyarbakir, Turkey
[5] Dicle Univ, Fac Vet Med, Dept Anat, TR-21280 Diyarbakir, Turkey
来源：
AFRICAN JOURNAL OF BIOTECHNOLOGY | 2009年 / 8卷 / 23期
关键词：
ICAM-1; rabbit; aorta endothelium; propofol; INTERCELLULAR-ADHESION MOLECULE-1; TRANSENDOTHELIAL MIGRATION; IN-VITRO; VCAM-1; COEFFICIENTS; SELECTIN; LFA-1;
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The dose-dependent effects of propofol on expression intracellular adhesion molecule (ICAM-1) in rabbit aorta endothelial cells was examined. Twenty adult New Zeland albino rabbits were used in this study. One control and three experimantal groups were designed. In experimantal groups; for group I propofol was not applied, group II 0.5, group III 4.0 and group IV 8.0 mg/kg propofol were applied to rabbits by marginal ear vein. One hour after applying propofol, control and experimantal group rabbits were sacrificed and their aorta were removed. The sections were stained with APAAP immunohistochemical staining for evaluation using a light microscope. This marked ICAM-1 immunoreactivity was maintained in 8.0 mg/kg of propofol applied to rabbits of aorta endothelium, whereas mild stain was observed for other experimantal groups. The present study indicated that there is parallel relationship between endothelial cells ICAM-1 expression and different doses of propofol.
引用
收藏
页码：6688 / 6693
页数：6
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