The oestrogen receptor GPER is expressed in human haematopoietic stem cells but not in mature megakaryocytes

被引:8
作者
Di Vito, Clara [1 ]
Bergante, Sonia [1 ]
Balduini, Alessandra [2 ]
Rastoldo, Alessandro [1 ]
Bagarotti, Alessandra [1 ]
Surico, Nicola [1 ]
Bertoni, Alessandra [1 ,3 ]
Sinigaglia, Fabiola [1 ,3 ]
机构
[1] Univ Piemonte Orientale, Dept Clin & Expt Med, Novara, Italy
[2] Univ Pavia, IRCCS Policlin San Matteo Fdn, Dept Biochem, I-27100 Pavia, Italy
[3] Univ Piemonte Orientale, Ctr Biotechnol Appl Med Res BRMA, Novara, Italy
关键词
megakaryocyte differentiation; G protein-coupled receptor 30; G protein-coupled oestrogen receptor; oestrogen receptor; platelet formation; HUMAN PLATELETS; BETA;
D O I
10.1111/j.1365-2141.2009.08028.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:150 / 152
页数:3
相关论文
共 10 条
[1]   Megakaryocyte population in human bone marrow increases with estrogen treatment: A role in bone remodeling? [J].
Bord, S ;
Vedi, S ;
Beavan, SR ;
Horner, A ;
Compston, JE .
BONE, 2000, 27 (03) :397-401
[2]   Estrogen stimulates differentiation of megakaryocytes and modulates their expression of estrogen receptors α and β [J].
Bord, S ;
Frith, E ;
Ireland, DC ;
Scott, MA ;
Craig, JIO ;
Compston, JE .
JOURNAL OF CELLULAR BIOCHEMISTRY, 2004, 92 (02) :249-257
[3]   Signaling by Estrogens [J].
Cheskis, Boris J. ;
Greger, James G. ;
Nagpal, Sunil ;
Freedman, Leonard P. .
JOURNAL OF CELLULAR PHYSIOLOGY, 2007, 213 (03) :610-617
[4]   Human megakaryocytes and platelets contain the estrogen receptor β and androgen receptor (AR):: testosterone regulates AR expression [J].
Khetawat, G ;
Faraday, N ;
Nealen, ML ;
Vijayan, KV ;
Bolton, E ;
Noga, SJ ;
Bray, PF .
BLOOD, 2000, 95 (07) :2289-2296
[5]   Megakaryopoiesis: Transcriptional insights into megakaryocyte maturation [J].
Kostyak, John C. ;
Naik, Ulhas P. .
FRONTIERS IN BIOSCIENCE-LANDMARK, 2007, 12 :2050-2062
[6]   Nongenomic effects of 17β-estradiol in human platelets:: potentiation of thrombin-induced aggregation through estrogen receptor and Src kinase [J].
Moro, L ;
Reineri, S ;
Piranda, D ;
Pietrapiana, D ;
Lova, P ;
Bertoni, A ;
Graziani, A ;
Defilippi, P ;
Canobbio, I ;
Torti, M ;
Sinigaglia, F .
BLOOD, 2005, 105 (01) :115-121
[7]   Proplatelet formation of megakaryocytes is triggered by autocrine-synthesized estradiol [J].
Nagata, Y ;
Yoshikawa, J ;
Hashimoto, A ;
Yamamoto, M ;
Payne, AH ;
Todokoro, K .
GENES & DEVELOPMENT, 2003, 17 (23) :2864-2869
[8]   The biogenesis of platelets from megakaryocyte propatelets [J].
Patel, SR ;
Hartwig, JH ;
Italiano, JE .
JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (12) :3348-3354
[9]   Effects of high-dose estrogen on murine hematopoietic bone marrow precede those on osteogenesis [J].
Perry, MJ ;
Samuels, A ;
Bird, D ;
Tobias, JH .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2000, 279 (05) :E1159-E1165
[10]   Membrane lipid rafts coordinate estrogen-dependent signaling in human platelets [J].
Reineri, Stefania ;
Bertoni, Alessandra ;
Sanna, Elena ;
Baldassarri, Samantha ;
Sarasso, Chiara ;
Zanfa, Manuela ;
Canobbio, Ilaria ;
Torti, Mauro ;
Sinigaglia, Fabiola .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2007, 1773 (02) :273-278