Agomelatine beyond Borders: Current Evidences of Its Efficacy in Disorders Other than Major Depression

被引：56

作者：

De Berardis, Domenico ^{[1
,2
]}

Fornaro, Michele ^{[3
]}

Serroni, Nicola ^{[2
]}

Campanella, Daniela ^{[2
]}

Rapini, Gabriella ^{[2
]}

Olivieri, Luigi ^{[1
]}

Srinivasan, Venkataramanujam ^{[4
]}

Iasevoli, Felice ^{[5
]}

Tomasetti, Carmine ^{[5
]}

De Bartolomeis, Andrea ^{[5
]}

Valchera, Alessandro ^{[6
]}

Perna, Giampaolo ^{[7
,8
,9
]}

Mazza, Monica ^{[10
]}

Di Nicola, Marco ^{[11
]}

Martinotti, Giovanni ^{[2
]}

Di Giannantonio, Massimo ^{[2
]}

机构：

[1] Hosp G Mazzini, Natl Hlth Serv, Dept Mental Hlth, Psychiat Serv Diag & Treatment, I-64100 Teramo, Italy

[2] Univ G dAnnunzio, Dept Neurosci & Imaging, I-66013 Chieti, Italy

[3] Univ Catania, Dept Sci Formaz, I-95121 Catania, Italy

[4] Med Sci Res Study Ctr, Sri Sathya Sai Med Educ & Res Fdn, Coimbatore 641014, Tamil Nadu, India

[5] Univ Sch Med Federico II, Lab Mol Psychiat & Psychopharmacotherapeut, Sect Psychiat, Dept Neurosci, I-80131 Naples, Italy

[6] Villa S Giuseppe Hosp, FoRiPsi, Hermanas Hosp, I-63100 Ascoli Piceno, Italy

[7] Hermanas Hosp, FoRiPsi, Dept Clin Neurosci, I-22032 Como, Italy

[8] Univ Miami, Leonard Miller Sch Med, Dept Psychiat & Behav Sci, Miami, FL 33124 USA

[9] Maastricht Univ, Dept Psychiat & Neuropsychol, NL-6200 MD Maastricht, Netherlands

[10] Univ Aquila, Dept Life Hlth & Environm Sci, I-67100 Laquila, Italy

[11] Univ Cattolica Sacro Cuore, Inst Psychiat & Psychol, I-00168 Rome, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2015年 / 16卷 / 01期

关键词：

melatonin; melatonergic receptors; serotonin; dopamine; noradrenaline; agomelatine; anxiety; bipolar depression; seasonal affective disorder; schizophrenia; alcohol dependence; migraines; fibromyalgia; psychiatric disorders; OBSESSIVE-COMPULSIVE DISORDER; GENERALIZED ANXIETY DISORDER; MELATONIN AGONIST AGOMELATINE; DOUBLE-BLIND; ANTIDEPRESSANT AGOMELATINE; CIRCADIAN-RHYTHM; REUPTAKE INHIBITORS; ADJUNCTIVE THERAPY; OPEN-LABEL; SCHIZOPHRENIA;

D O I：

10.3390/ijms16011111

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Agomelatine, a melatonergic antidepressant with a rapid onset of action, is one of the most recent drugs in the antidepressant category. Agomelatine's antidepressant actions are attributed to its sleep-promoting and chronobiotic actions mediated by MT1 and MT2 receptors present in the suprachiasmatic nucleus, as well as to its effects on the blockade of 5-HT2c receptors. Blockade of 5-HT2c receptors causes release of both noradrenaline and dopamine at the fronto-cortical dopaminergic and noradrenergic pathways. The combined actions of agomelatine on MT1/MT2 and 5-HT2c receptors facilitate the resynchronization of altered circadian rhythms and abnormal sleep patterns. Agomelatine appeared to be effective in treating major depression. Moreover, evidence exists that points out a possible efficacy of such drug in the treatment of bipolar depression, anxiety disorders, alcohol dependence, migraines etc. Thus, the aim of this narrative review was to elucidate current evidences on the role of agomelatine in disorders other than major depression.

引用

页码：1111 / 1130

页数：20

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