p53 activation: a checkpoint for precision genome editing?

被引：14
作者：
Conti, Anastasia [1 ]
Di Micco, Raffaella [1 ]
机构：
[1] San Raffaele Telethon Inst Gene Therapy, Via Olgettina 60, I-20132 Milan, Italy
来源：
GENOME MEDICINE | 2018年 / 10卷
关键词：
CELLS;
D O I：
10.1186/s13073-018-0578-6
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Recent work has reported that the activation of the p53 pathway in primary cells hampers the efficiency of genome editing by CRISPR/Cas9 via induction of apoptosis or cell cycle arrest. These findings highlight the importance of wholly comprehending cellular responses to programmable nucleases in therapeutically relevant cell types to fulfill the promise of genome editing for therapeutic applications for human diseases.
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页数：4
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