Delayed follow-up in patients with diabetic retinopathy in South India: Social factors and impact on disease progression

Purpose: To identify social factors associated with delayed follow-up in South Indian patients with diabetic retinopathy (DR) and to study DR progression during the delayed follow-up period. Materials and Methods: In this cross-sectional study, 500 consecutive patients with DR returning after greater than twice the advised follow-up period were identified from a tertiary referral center in South India. A previously validated 19-item questionnaire was administered to study patients to assess causes for the follow-up delay. Patient demographics, DR status, and treatment plan were recorded at the study visit and the visit immediately before the delay. The eye with the most severe disease was included in the analysis. Results: Complete data were available for 491 (98.2%) patients. Among these, 248 (50.5%) cited "my eyes were okay at the time," 201 (41.0%) cited "no attender to accompany me," and 190 (38.6%) cited "financial cost" as causes of the follow-up delay. Those with vision-threatening DR (VTDR, n = 233) predominantly reported " financial cost" (47% vs. 32%, P = 0.001), whereas those with non-VTDR more frequently reported " my eyes were okay at the time" (58% vs. 42%, P = 0.001). Evidence of disease progression from non-VTDR to VTDR was seen in 67 (26%) patients. Almost 1/3rd (29%) of patients who were previously advised regular examination required additional intervention. Conclusion: Many patient-level factors affect poor compliance with follow-up in DR, and these factors vary by disease severity. Targeting these barriers to care through patient education and clinic procedures may promote timely follow-up and better outcomes in these patients.