Synthesis and deprotection of oligonucleotides under aprotic conditions

被引：6

作者：

Chen, TQ ^{[1
]}

Fu, JS ^{[1
]}

Greenberg, MM ^{[1
]}

机构：

[1] Colorado State Univ, Dept Chem, Ft Collins, CO 80523 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 23期

关键词：

D O I：

10.1021/ol006604p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Oligonucleotides containing an alkali labile nucleotide are synthesized and deprotected using a synthetic method that eliminates the use of Bronsted acid and base. The development of a new family of exocyclic amine protecting groups is an integral component of this approach.

引用

页码：3691 / 3694

页数：4

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