Tenofovir-related nephrotoxicity in human immunodeficiency virus-infected patients: Three cases of renal failure, Fanconi syndrome, and nephrogenic diabetes insipidus

被引：270

作者：

Karras, A

Lafaurie, M

Furco, A

Bourgarit, A

Droz, D

Sereni, D

Legendre, C

Martinez, F

Molina, JM

机构：

[1] Hop St Louis, Serv Nephrol, F-75475 Paris 10, France

[2] Hop St Louis, Serv Malad Infect & Trop, F-75475 Paris, France

[3] Hop St Louis, Serv Anat Pathol, F-75475 Paris 10, France

[4] Hop St Louis, Serv Med Interne, F-75475 Paris 10, France

来源：

CLINICAL INFECTIOUS DISEASES | 2003年 / 36卷 / 08期

关键词：

D O I：

10.1086/368314

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We report 3 cases of renal toxicity associated with use of the antiviral agent tenofovir. Renal failure, proximal tubular dysfunction, and nephrogenic diabetes insipidus were observed, and, in 2 cases, renal biopsy revealed severe tubular necrosis with characteristic nuclear changes. Patients receiving tenofovir must be monitored closely for early signs of tubulopathy (glycosuria, acidosis, mild increase in the plasma creatinine level, and proteinuria).

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页码：1070 / 1073

页数：4

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