Genetic characterization and phylogenic analysis of H5N1 avian influenza virus detected in peafowl in Kirkuk province, Iraq

被引：7
作者：
Rashid, Peshnyar M. A. [1 ]
Saeed, Nahla M. [2 ]
Dyary, Hiewa Othman [2 ]
机构：
[1] Slemani Vet Directorate, Mol Diagnost Lab, As Sulaymaniyah, Kurdistan Regio, Iraq
[2] Univ Sulaimani, Coll Vet Med, Basic Sci Dept, As Sulaymaniyah, Kurdistan Regio, Iraq
来源：
JOURNAL OF MEDICAL VIROLOGY | 2017年 / 89卷 / 07期
关键词：
H5N1; highly-pathogenic avian influenza; Iraq; SENSITIVITY;
D O I：
10.1002/jmv.24762
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A highly pathogenic avian influenza (HPAI), H5N1, was detected for the first time in peafowls in Kirkuk province, Iraq in 2015. Genetic analysis of the Kirkuk H5N1 indicated molecular markers for avian-type receptors. The Kirkuk H5N1 hemagglutinin gene had an infrequent amino acid cleavage site (SPQREKRRKRGLF), and neuraminidase genes showed sensitive molecular markers for antiviral drugs. Additionally, the phylogenetic analysis found that the Kirkuk H5N1 belonged to subclade 2.3.2.1c. Our results showed that the 2015 H5N1 from the Iraqi city of Kirkuk exhibited new genetic characterization and was different from the 2006 H5N1 isolate from Iraq.
引用
收藏
页码：1179 / 1185
页数：7
相关论文
共 25 条
[1]  
Aubin JT, 2005, EMERG INFECT DIS, V11, P1515
[2]   An avian influenza H5N1 virus that binds to a human-type receptor [J].
Auewarakul, Prasert ;
Suptawiwat, Ornpreya ;
Kongchanagul, Alita ;
Sangma, Chak ;
Suzuki, Yasuo ;
Ungchusak, Kumnuan ;
Louisirirotchanakul, Suda ;
Lerdsamran, Hatairat ;
Pooruk, Phisanu ;
Thitithanyanont, Arunee ;
Pittayawonganon, Chakrarat ;
Guo, Chao-Tan ;
HiramatSU, Hiroaki ;
Jampangern, Wipawee ;
Chunsutthiwat, Supamit ;
Puthavathanal, Pilaipan .
JOURNAL OF VIROLOGY, 2007, 81 (18) :9950-9955
[3]   Emergence of H5N1 avian influenza viruses with reduced sensitivity to neuraminidase inhibitors and novel reassortants in Lao People's Democratic Republic [J].
Boltz, David A. ;
Douangngeun, Bounlom ;
Phommachanh, Phouvong ;
Sinthasak, Settha ;
Mondry, Ricarda ;
Obert, Caroline ;
Seiler, Patrick ;
Keating, Rachael ;
Suzuki, Yasuo ;
Hiramatsu, Hiroaki ;
Govorkova, Elena A. ;
Webster, Robert G. .
JOURNAL OF GENERAL VIROLOGY, 2010, 91 :949-959
[4]   Ambient Influenza and Avian Influenza Virus during Dust Storm Days and Background Days [J].
Chen, Pei-Shih ;
Tsai, Feng Ta ;
Lin, Chien Kun ;
Yang, Chun-Yuh ;
Chan, Chang-Chuan ;
Young, Chea-Yuan ;
Lee, Chien-Hung .
ENVIRONMENTAL HEALTH PERSPECTIVES, 2010, 118 (09) :1211-1216
[5]   Bird Migration and Risk for H5N1 Transmission into Qinghai Lake, China [J].
Cui, Peng ;
Hou, Yuansheng ;
Xing, Zhi ;
He, Yubang ;
Li, Tianxian ;
Guo, Shan ;
Luo, Ze ;
Yan, Baoping ;
Yin, Zuohua ;
Lei, Fumin .
VECTOR-BORNE AND ZOONOTIC DISEASES, 2011, 11 (05) :567-576
[6]   Molecular characterization of a H5N1 highly pathogenic avian influenza virus clade 2.3.2.1b circulating in Vietnam in 2011 [J].
Dau Huy Tung ;
Dong Van Quyen ;
Tung Nguyen ;
Hanh Tran Xuan ;
Thang Nguyen Nam ;
Khang Dinh Duy .
VETERINARY MICROBIOLOGY, 2013, 165 (3-4) :341-348
[7]   Clinical predictors of disease severity during the 2009-2010 A(HIN1) influenza virus pandemic in a paediatric population [J].
Garcia, M. N. ;
Philpott, D. C. ;
Murray, K. O. ;
Ontiveros, A. ;
Revell, P. A. ;
Chandramohan, L. ;
Munoz, F. M. .
EPIDEMIOLOGY AND INFECTION, 2015, 143 (14) :2939-2949
[8]   Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses [J].
Hatta, M ;
Gao, P ;
Halfmann, P ;
Kawaoka, Y .
SCIENCE, 2001, 293 (5536) :1840-1842
[9]   Characterization of a Novel Influenza Virus in Cattle and Swine: Proposal for a New Genus in the Orthomyxoviridae Family [J].
Hause, Ben M. ;
Collin, Emily A. ;
Liu, Runxia ;
Huang, Bing ;
Sheng, Zizhang ;
Lu, Wuxun ;
Wang, Dan ;
Nelson, Eric A. ;
Li, Feng .
MBIO, 2014, 5 (02)
[10]   Complete Genome Sequence of the First H5N1 Avian Influenza Virus Isolated from Chickens in Lebanon in 2016 [J].
Ibrahim, Elias ;
Sirawan, Abeer ;
El-Bazzal, Bassel ;
El Hage, Jeanne ;
Said, Mounir Abi ;
Zaraket, Hassan ;
Kandeil, Ahmed ;
Ali, Mohamed A. ;
Kayali, Ghazi .
GENOME ANNOUNCEMENTS, 2016, 4 (05)
123