Role of genomics in combating COVID-19 pandemic

被引：32

作者：

Saravanan, K. A. ^{[1
]}

Panigrahi, Manjit ^{[1
]}

Kumar, Harshit ^{[1
]}

Rajawat, Divya ^{[1
]}

Nayak, Sonali Sonejita ^{[1
]}

Bhushan, Bharat ^{[1
]}

Dutt, Triveni ^{[2
]}

机构：

[1] Indian Vet Res Inst, Div Anim Genet, Bareilly 243122, Uttar Pradesh, India

[2] Indian Vet Res Inst, Livestock Prod & Management Sect, Bareilly 243122, Uttar Pradesh, India

来源：

GENE | 2022年 / 823卷

关键词：

COVID-19; Genomics; Genomic surveillance; Reverse vaccinology; SARS-CoV-2; SARS-COV-2; GENOMES; VACCINE; RNA; VARIANTS; TOCILIZUMAB; LANDSCAPE; IMPACT; SAFETY;

D O I：

10.1016/j.gene.2022.146387

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The coronavirus disease 2019 (COVID-19) quickly swept over the world, becoming one of the most devastating outbreaks in human history. Being the first pandemic in the post-genomic era, advancements in genomics contributed significantly to scientific understanding and public health response to COVID-19. Genomic technologies have been employed by researchers all over the world to better understand the biology of SARS-CoV-2 and its origin, genomic diversity, and evolution. Worldwide genomic resources have greatly aided in the investigation of the COVID-19 pandemic. The pandemic has ushered in a new era of genomic surveillance, wherein scientists are tracking the changes of the SARS-CoV-2 genome in real-time at the international and national levels. Availability of genomic and proteomic information enables the rapid development of molecular diagnostics and therapeutics. The advent of high-throughput sequencing and genome editing technologies led to the development of modern vaccines. We briefly discuss the impact of genomics in the ongoing COVID-19 pandemic in this review.

引用

页数：11

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