Cell Cycle Regulators and Lineage-Specific Therapeutic Targets for Cushing Disease

被引：7
|
作者：
Araki, Takako [1 ]
Liu, Ning-Ai [2 ]
机构：
[1] Univ Minnesota, Dept Med, Div Diabet Endocrinol & Metab, Box 736 UMHC, Minneapolis, MN 55455 USA
[2] Cedars Sinai Med Ctr, Dept Med, Pituitary Ctr, Los Angeles, CA 90048 USA
来源：
FRONTIERS IN ENDOCRINOLOGY | 2018年 / 9卷
关键词：
pituitary tumor; Cushing disease; cell cycle; cyclin E; E2F1; POMC; MULTIPLE ENDOCRINE NEOPLASIA; HUMAN PITUITARY-ADENOMAS; RETINOBLASTOMA SUSCEPTIBILITY GENE; GROWTH-FACTOR RECEPTOR; TUMOR-SUPPRESSOR GENE; DEPENDENT KINASES; INHIBITOR P27; CORTICOTROPH TUMORS; CDK INHIBITOR; MICE LACKING;
D O I：
10.3389/fendo.2018.00444
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Cell cycle proteins are critical to pituitary development, but their contribution to lineage-specific tumorigenesis has not been well-elucidated. Emerging evidence from in vitro human tumor analysis and transgenic mouse models indicates that G1/S-related cell cycle proteins, particularly cyclin E, p27, Rb, and E2F1, drive molecular mechanisms that underlie corticotroph-specific differentiation and development of Cushing disease. The aim of this review is to summarize the literature and discuss the complex role of cell cycle regulation in Cushing disease, with a focus on identifying potential targets for therapeutic intervention in patients with these tumors.
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页数：8
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