Iridoids from the aerial parts of Verbena littoralis (Verbenaceae)

被引：17
作者：
Castro-Gamboa, I
Castro, O
机构：
[1] Univ Estadual Paulista, NuBBE, BR-14801970 Sao Paulo, Brazil
[2] Univ Nacl Heredia UNA, Dept Quim, Heredia, Costa Rica
来源：
PHYTOCHEMISTRY | 2004年 / 65卷 / 16期
基金：
巴西圣保罗研究基金会;
关键词：
Verbena littoralis; Verbenaceae; iridoids; antibacterial activity; antioxidant;
D O I：
10.1016/j.phytochem.2004.07.008
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The iridoids, 6S-hydroxy-8S-methyl-4-methylene-hexahydro-cyclopenta[c]pyran-3-one and 6S,9S-dihydroxy-8S-methyl-4methylene-hexahydro-cyclopenta[c]pyran-3-one, were isolated from the aerial parts of Verbena littoralis. Their structures and stereochemistry were elucidated by means of NMR spectral data analysis. Both compounds showed moderate in vitro activity against gram positive and negative bacteria as well as moderate in vivo intestinal peristaltic action in mouse. The iridoids also showed moderate free radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) as well as antioxidant activity, the latter being evidenced by redox properties measured using EICD-HPLC. (C) 2004 Elsevier Ltd. All rights reserved.
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页码：2369 / 2372
页数：4
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