Fabrication, characterization and drug goading of pH-dependent multi-morphoogica nanoparticles based on cellulose

被引：27
作者：
Dou, Hongjing
Jiang, Ming
机构：
[1] Shanghai Jiao Tong Univ, Sch Mat Sci & Engn, Shanghai 200030, Peoples R China
[2] Shanghai Jiao Tong Univ, State Key Lab Met Matxix Composites, Shanghai 200030, Peoples R China
[3] Fudan Univ, Minist Educ, Key Lab Mol Engn Polymers, Dept Macromol Sci, Shanghai 200433, Peoples R China
来源：
POLYMER INTERNATIONAL | 2007年 / 56卷 / 10期
关键词：
nanoparticles; self-assembly; cellulose; poly(acrylic acid);
D O I：
10.1002/pi.2259
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
This paper investigates the pH-dependent micellization of (hydroxyethyl ceflulose)-graft-poly(acrylic acid) (HEC-graft-PAA), the crosslinking of the pH-induced nanoparticles and the drug loading of the crosslinked multi-morphological nanoparticles. The hydrodynamic diameter (< Dh >) of the pH-induced micelles was found dependent on both temperature and concentration in dynamic light scattering studies. After the crosslinking of PAA segments in the micelles, shape-persistent nanoparticles were obtained, which exhibited multiple morphologies from nano-cage to hollow sphere, and a homogeneous swollen microgel in neutral medium with an increase of the degree of crosslinking. To investigate the drug loading of these shape-persistant nanoparticles, diminazene aceturate was chosen as a model drug. The loading efficiency and the drug release behavior against water and 0.1 mol L-1 NaCl were studied using UV absorption spectroscopy. (c) 2007 Society of Chemical Industry
引用
收藏
页码：1206 / 1212
页数：7
相关论文
共 36 条
[1]  
Brandrup J, 1989, POLYM HDB
[2]   Interaction of metal compounds with 'double-hydrophilic' block copolymers in aqueous medium and metal colloid formation [J].
Bronstein, LM ;
Sidorov, SN ;
Gourkova, AY ;
Valetsky, PM ;
Hartmann, J ;
Breulmann, M ;
Colfen, H ;
Antonietti, M .
INORGANICA CHIMICA ACTA, 1998, 280 (1-2) :348-354
[3]  
BUCHARD W, 1996, LIGHT SCATTERING PRI, P439
[4]   Unusual aggregation behavior of a novel tertiary amine methacrylate-based diblock copolymer: Formation of micelles and reverse micelles in aqueous solution [J].
Butun, V ;
Billingham, NC ;
Armes, SP .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (45) :11818-11819
[5]   Radical emulsion polymerization of alkylcyanoacrylates initiated by the redox system dextran-cerium(IV) under acidic aqueous conditions [J].
Chauvierre, C ;
Labarre, D ;
Couvreur, P ;
Vauthier, C .
MACROMOLECULES, 2003, 36 (16) :6018-6027
[6]  
Cölfen H, 2001, MACROMOL RAPID COMM, V22, P219, DOI 10.1002/1521-3927(20010201)22:4<219::AID-MARC219>3.0.CO
[7]  
2-G
[8]  
Donath E, 1998, ANGEW CHEM INT EDIT, V37, P2202, DOI 10.1002/(SICI)1521-3773(19980904)37:16<2201::AID-ANIE2201>3.0.CO
[9]  
2-E
[10]   A facile one-pot synthesis to dextran-based nanoparticles with carboxy functional groups [J].
Dou, HJ ;
Tang, MH ;
Sun, K .
MACROMOLECULAR CHEMISTRY AND PHYSICS, 2005, 206 (21) :2177-2181
1234