Anticancer and apoptosis-inducing effects of quercetin in vitro and in vivo

被引：367

作者：

Hashemzaei, Mahmoud ^{[1
,2
]}

Far, Amin Delarami ^{[1
,2
]}

Yari, Arezoo ^{[1
,2
]}

Heravi, Reza Entezari ^{[2
,3
]}

Tabrizian, Kaveh ^{[1
,2
]}

Taghdisi, Seyed Mohammad ^{[4
]}

Sadegh, Sarvenaz Ekhtiari ^{[2
]}

Tsarouhas, Konstantinos ^{[5
]}

Kouretas, Dimitrios ^{[6
]}

Tzanakakis, George ^{[7
]}

Nikitovic, Dragana ^{[7
]}

Anisimov, Nikita Yurevich ^{[8
]}

Spandidos, Demetrios A. ^{[9
]}

Tsatsakis, Aristides M. ^{[10
]}

Rezaee, Ramin ^{[11
]}

机构：

[1] Zabol Univ Med Sci, Dept Pharmacol & Toxicol, Fac Pharm, Zabol, Iran

[2] Zabol Univ Med Sci, Students Res Comm, Sch Pharm, Zabol, Iran

[3] Zabol Univ Med Sci, Dept Pharmaceut Biotechnol, Fac Pharm, Zabol, Iran

[4] Mashhad Univ Med Sci, Sch Pharm, Targeted Drug Delivery Res Ctr, Mashhad, Iran

[5] Larissa Univ Hosp, Dept Cardiol, Larisa, Greece

[6] Univ Thessaly, Fac Anim Physiol Toxicol, Dept Biochem & Biotechnol, Larisa, Greece

[7] Univ Crete, Med Sch, Dept Anat Histol Embryol, Iraklion, Greece

[8] Far Eastern Fed Univ, Engn Sch, SEC Nanotechnol, Vladivostok, Russia

[9] Univ Crete, Fac Med, Lab Clin Virol, Iraklion, Greece

[10] Univ Crete, Fac Med, Dept Forens Sci & Toxicol, Iraklion, Greece

[11] Mashhad Univ Med Sci, Clin Res Unit, Fac Med, Mashhad, Iran

来源：

ONCOLOGY REPORTS | 2017年 / 38卷 / 02期

关键词：

quercetin; apoptosis; cytotoxicity; Annexin V/PI; cancer treatment; MTT assay; CANCER CELL-GROWTH; FLAVONOID QUERCETIN; ANTITUMOR-ACTIVITY; DIETARY POLYPHENOLS; NATURAL-PRODUCTS; TYROSINE KINASE; HUMAN HEALTH; INHIBITION; BREAST; ANTIOXIDANT;

D O I：

10.3892/or.2017.5766

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The present study focused on the elucidation of the putative anticancer potential of quercetin. The anticancer activity of quercetin at 10, 20, 40, 80 and 120 mu M was assessed in vitro by MMT assay in 9 tumor cell lines (colon carcinoma CT-26 cells, prostate adenocarcinoma LNCaP cells, human prostate PC3 cells, pheocromocytoma PC12 cells, estrogen receptor-positive breast cancer MCF-7 cells, acute lymphoblastic leukemia MOLT-4 T-cells, human myeloma U266B1 cells, human lymphoid Raji cells and ovarian cancer CHO cells). Quercetin was found to induce the apoptosis of all the tested cancer cell lines at the utilized concentrations. Moreover, quercetin significantly induced the apoptosis of the CT-26, LNCaP, MOLT -4 and Raji cell lines, as compared to control group (P4.001), as demonstrated by Annexin V/PI staining. In in vivo experiments, mice bearing MCF-7 and CT-26 tumors exhibited a significant reduction in tumor volume in the quercetin-treated group as compared to the control group (P<0.001). Taken together, quercetin, a naturally occurring compound, exhibits anticancer properties both in vivo and in vitro.

引用

页码：819 / 828

页数：10

共 100 条

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