Copper-Catalyzed Three-Component Domino Cyclization for the Synthesis of 4-Aryl-5-(arythio)-2-(trifluoromethyl)oxazoles

被引：49

作者：

Xiao, Fuhong ^{[1
]}

Yuan, Shanshan ^{[1
]}

Huang, Huawen ^{[1
]}

Zhang, Feng ^{[2
]}

Deng, Guo-Jun ^{[1
]}

机构：

[1] Xiangtan Univ, Coll Chem, Key Lab Environm Friendly Chem & Applicat, Minist Educ,Key Lab Green Organ Synth & Applicat, Xiangtan 411105, Peoples R China

[2] Hunan Agr Univ, Coll Sci, Changsha 410128, Hunan, Peoples R China

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 21期

基金：

中国国家自然科学基金;

关键词：

C-H FUNCTIONALIZATION; OXIME ACETATES; METAL-FREE; EFFICIENT SYNTHESIS; POLYSUBSTITUTED PYRIDINES; ACCESS; DERIVATIVES; OXAZOLES; CLEAVAGE; INDOLES;

D O I：

10.1021/acs.orglett.9b02934

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A copper-catalyzed oxidative cyclization of oxime, arylthiol, and trifluoroacetic anhydride for the construction of trisubstituted oxazoles has been developed. This transformation combines N-O bond cleavage, C-H functionalization, and intramolecular annulation, providing a practical protocol for the introduction of a trifluoromethyl (-CF3) group at oxazole rings.

引用

页码：8533 / 8536

页数：4

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