DEVELOPMENT AND CHARACTERIZATION OF A NOVEL VARIABLE LOW DOSE-RATE IRRADIATOR FOR IN VIVO MOUSE STUDIES

被引:2
作者
Olipitz, Werner [2 ]
Hembrador, Sheena [1 ]
Davidson, Matthew [1 ]
Yanch, Jacquelyn C. [1 ,2 ]
Engelward, Bevin P. [2 ]
机构
[1] MIT, Dept Nucl Sci & Engn, Cambridge, MA 02139 USA
[2] MIT, Dept Biol Engn, Cambridge, MA 02139 USA
来源
HEALTH PHYSICS | 2010年 / 98卷 / 05期
关键词
dose; low; I-125; mice; radiation effects; TRITIATED-WATER HTO; MAMMALIAN-CELLS; GAMMA-RAYS; IONIZING-RADIATION; DNA-DAMAGE; EXPOSURE; VITRO; INDUCTION; THRESHOLD; REPAIR;
D O I
10.1097/HP.0b013e3181d26dc5
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Radiation exposure of humans generally results in low doses delivered at low dose rate. Our limited knowledge of the biological effects of low dose radiation is mainly based on data from the atomic bomb Life Span Study (LSS) cohort. However, the total doses and dose rates in the LSS cohort are still higher than most environmental and occupational exposures in humans. Importantly, the dose rate is a critical determinant of health risks stemming from radiation exposure. Understanding the shape of the dose-rate response curve for different biological outcomes is thus crucial for projecting the biological hazard from radiation in different environmental and man-made conditions. A significant barrier to performing low dose-rate studies is the difficulty in creating radiation source configurations compatible with long-term cellular or animal experiments. In this study the design and characterization of a large area, I-125-based irradiator is described. The irradiator allows continuous long-term exposure of mice at variable dose rates and can be sited in standard animal care facilities. The dose rate is determined by the level of I-125 activity added to a large NaOH-filled rectangular phantom. The desired dose rate is maintained at essentially constant levels by weekly additions of I-125 to compensate for decay. Dosimetry results for long-term animal irradiation at targeted dose rates of 0.00021 and 0.0021 cGy min(-1) are presented. Health Phys. 98(5):727-734; 2010
引用
收藏
页码:727 / 734
页数:8
相关论文
共 27 条
  • [1] A purpose-built iodine-125 irradiation plaque for low dose rate low energy irradiation of cell lines in vitro
    Aird, EG
    Folkard, M
    Mayes, CR
    Bownes, PJ
    Lawson, JM
    Joiner, MC
    [J]. BRITISH JOURNAL OF RADIOLOGY, 2001, 74 (877) : 56 - 61
  • [2] DOSE-RATE EFFECTS IN SYNCHRONOUS MAMMALIAN-CELLS IN CULTURE
    BEDFORD, JS
    MITCHELL, JB
    [J]. RADIATION RESEARCH, 1973, 54 (02) : 316 - 327
  • [3] Cancer risks attributable to low doses of ionizing radiation: Assessing what we really know
    Brenner, DJ
    Doll, R
    Goodhead, DT
    Hall, EJ
    Land, CE
    Little, JB
    Lubin, JH
    Preston, DL
    Preston, RJ
    Puskin, JS
    Ron, E
    Sachs, RK
    Samet, JM
    Setlow, RB
    Zaider, M
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (24) : 13761 - 13766
  • [4] Collin L., 2006, International Journal of Low Radiation, V2, P34, DOI 10.1504/IJLR.2006.007894
  • [5] Low doses of very low-dose-rate low-LET radiation suppress radiation-induced neoplastic transformation in vitro and induce an adaptive response
    Elmore, E.
    Lao, X-Y.
    Kapadia, R.
    Giedzinski, E.
    Limoli, C.
    Redpath, J. L.
    [J]. RADIATION RESEARCH, 2008, 169 (03) : 311 - 318
  • [6] THE EFFECT OF DOSE-RATE ON X-RADIATION-INDUCED MUTANT FREQUENCY AND THE NATURE OF DNA LESIONS IN MOUSE LYMPHOMA L5178Y CELLS
    EVANS, HH
    NIELSEN, M
    MENCL, J
    HORNG, MF
    RICANATI, M
    [J]. RADIATION RESEARCH, 1990, 122 (03) : 316 - 325
  • [7] Firestone R.B., 1999, Table of isotopes
  • [8] Howell RW, 1997, J NUCL MED, V38, P727
  • [9] *IAE AG, 1980, INFCIRC274REV1 IAEA
  • [10] *IAE AG, 2005, RSG19 IAEA