Novel 2,4,6-Trimethylbenzenesulfonyl Hydrazones with Antibacterial Activity: Synthesis and In Vitro Study

被引：4

作者：

Popiolek, Lukasz ^{[1
]}

Szeremeta, Sylwia ^{[1
]}

Biernasiuk, Anna ^{[2
]}

Wujec, Monika ^{[1
]}

机构：

[1] Med Univ Lublin, Fac Pharm, Dept Organ Chem, 4A Chodzki St, PL-20093 Lublin, Poland

[2] Med Univ Lublin, Fac Pharm, Dept Pharmaceut Microbiol, 1 Chodzki St, PL-20093 Lublin, Poland

来源：

MATERIALS | 2021年 / 14卷 / 11期

关键词：

benzenesulfonyl hydrazones; bioactivity; antibacterial activity; MIC; MBC; ligands; SULFONYL HYDRAZONES; SPECTROSCOPIC CHARACTERIZATION; ANTIMICROBIAL EVALUATION; BIOLOGICAL EVALUATION; ANTIFUNGAL ACTIVITY; N-TOSYLHYDRAZONES; DERIVATIVES; PALLADIUM(II); PLATINUM(II); NICKEL(II);

D O I：

10.3390/ma14112723

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

This research describes the synthesis and in vitro antimicrobial activity study of a series of 2,4,6-trimethylbenzenesulfonyl hydrazones. Twenty-five hydrazones (2-26) were synthesized on the basis of condensation reaction. The in vitro bioactivity study confirmed the potential application of obtained derivatives as antimicrobial agents. Among the tested compounds, the highest activity was discovered for derivative 24, which possessed minimal inhibitory concentration (MIC) ranging from 7.81 to 15.62 mu g/mL against Gram-positive reference bacterial strains. Synthesized benzenesulfonyl hydrazones can be applied as potential ligands for the synthesis of bioactive metal complexes.

引用

页数：13

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