Application of Human Umbilical Cord Mesenchymal Stem Cells in Spinal Cord Injury

被引：3
|
作者：
Yang, Peng [1 ]
Li, Yun [2 ]
Zhang, Jing-Tao [1 ]
Wang, Lin-Feng [1 ]
Shen, Yong [1 ]
机构：
[1] Hebei Med Univ, Dept Spine Surg, Hosp 3, Shijiazhuang 050051, Peoples R China
[2] North China Univ Sci & Technol, Sch Publ Hlth, Dept Epidemiol & Stat, Tanshan 063000, Peoples R China
来源：
JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING | 2017年 / 7卷 / 05期
关键词：
Human; Umbilical Cord Mesenchymal Stem Cells; Neurons; Spinal Cord Injury;
D O I：
10.1166/jbt.2017.1583
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
In this research, we induced human umbilical cord mesenchymal stem cells (hUCMSCs) into neurons using different protocols and evaluated differentiation efficiency, and then hUCMSCs derived neurons were used to therapy spinal cord injury. MBP and MAP-2 were used markers for neurons to detect differentiated cells from hUCMSCs. The results indicated that transgenes (Nurr-1) combined with cocktail factors (including ATRA, GGF-2, bFGF, PDGF and forskolin) was best protocol for neurons differentiation from hUCMSCs and hUCMSCs-derived neurons were successfully colonized into injured spinal cord, which suggested participation in tissue repair.
引用
收藏
页码：393 / 400
页数：8
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