CircRNA microarray profiling identifies a novel circulating biomarker for detection of gastric cancer

被引：229

作者：

Tang, Weiwei ^{[1
]}

Fu, Kai ^{[1
]}

Sun, Handong ^{[1
]}

Rong, Dawei ^{[1
]}

Wang, Hanjin ^{[1
]}

Cao, Hongyong ^{[1
]}

机构：

[1] Nanjing Med Univ, Nanjing Hosp 1, Dept Gen Surg, Nanjing, Jiangsu, Peoples R China

来源：

MOLECULAR CANCER | 2018年 / 17卷

关键词：

circRNAs; Microarray; Biomarker; Exosomes; Plasma;

D O I：

10.1186/s12943-018-0888-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

CircRNA expression profiles for gastric cancer (GC) were screened using plasma samples from 10 GC patients with different TNM stages and 5 healthy individuals as controls. Results showed lower expression of circ-KIAA1244 in GC tissues, plasmas, and cells compare to normal controls. Further clinical data analysis demonstrated that a decreased expression of circ-KIAA1244 in plasmas was negatively correlated with TNM stage and lymphatic metastasis, and a shorter overall survival time of GC patients. Moreover, we found that circ-KIAA1244 could be detected in GC plasma exosomes and showed no obvious significance compared to the expression level in the corresponding plasmas. This study revealed a GC-tissues-derived circ-KIAA1244 could serve a novel circulating biomarker for detection of GC.

引用

页数：6

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