Rapid separation of basic drugs by nonaqueous capillary electrophoresis

被引：26

作者：

Cherkaoui, S ^{[1
]}

Geiser, L ^{[1
]}

Veuthey, JL ^{[1
]}

机构：

[1] Univ Geneva, Lab Pharmaceut Analyt Chem, CH-1211 Geneva 4, Switzerland

来源：

CHROMATOGRAPHIA | 2000年 / 52卷 / 7-8期

关键词：

nonaqueous capillary electrophoresis; rapid separation; pharmaceuticals; organic solvents;

D O I：

10.1007/BF02535710

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Nonaqueous capillary electrophoresis (NACE) has been used to achieve rapid separations of basic drugs. A high electric field was obtained by using short capillaries, Baseline separations of basic drugs, including amphetamines, tropane alkaloids and local anesthetics, were achieved in I min by selection of the appropriate organic solvent and electrolyte composition. Thus, high-throughput analyses can be performed. Peak efficiency up to 9154 theoretical plates s(-1) was achieved in a separation performed at 923Vcm(-1). No discernible loss in resolution was observed when a conventional capillary (64.5cm) was replaced by a short (32.5cm) capillary.

引用

页码：403 / 407

页数：5

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