Modeling schizophrenia in flies

被引：8

作者：

Furukubo-Tokunaga, Katsuo ^{[1
]}

机构：

[1] Univ Tsukuba, Grad Sch Life & Environm Sci, Tsukuba, Ibaraki, Japan

来源：

GENETIC MODELS OF SCHIZOPHRENIA | 2009年 / 179卷

关键词：

schizophrenia; genetic model; Drosophila; sleep; cAMP; ATF; mushroom body; GENE-EXPRESSION; DISRUPTED-IN-SCHIZOPHRENIA-1; DISC1; DROSOPHILA MODEL; BRAIN ACTIVITY; FRUIT-FLY; SLEEP; MEMORY; ASSOCIATION; TRANSLOCATION; IMPAIRMENT;

D O I：

10.1016/S0079-6123(09)17912-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Schizophrenia is a debilitating mental illness that affects 1% of the population worldwide. Although its molecular etiology remains unclear, recent advances in human psychiatric genetics have identified a large number of candidate genetic risk factors involved in schizophrenia. Modeling the disease in genetically tractable animals is thus a challenging but increasingly important task. In this review, I discuss the potential problems and perspectives associated with modeling schizophrenia in fruit flies, and briefly review the recent studies analyzing the molecular and cellular functions of Disrupted-In-Schizophrenia-1 (DISC1) in transgenic flies.

引用

页码：107 / 115

页数：9

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