An efficient synthesis of the 25-hydroxy Windaus-Grundmann ketone

被引：12

作者：

Fall, Y ^{[1
]}

Vitale, C

Mouriño, A

机构：

[1] Univ Vigo, Fac Ciencias, Dept Quim Fis & Quim Organ, Vigo 36200, Spain

[2] Univ Santiago de Compostela, Dept Quim Organ, Santiago De Compostela 15706, Spain

[3] Univ Santiago de Compostela, CSIC, Unidad Asociada, Santiago De Compostela 15706, Spain

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 38期

关键词：

D O I：

10.1016/S0040-4039(00)01224-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A short and efficient synthesis of the 25-hydroxy Windaus-Grundmann ketone from the Inhoffen-Lythgoe diol is described (seven steps, 70% overall). The most relevant feature of the synthesis is the preparation of the Wittig reagent 3 from cheap and commercially available starting materials. Pure 3 can be obtained in multigram quantities for achieving clean and efficient Wittig reactions. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：7337 / 7340

页数：4

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