AMPA, kainate, and NMDA receptor densities in the hippocampus of untreated male rats and females in estrus and diestrus

被引:49
作者
Palomero-Gallagher, N [1 ]
Bidmon, HJ
Zilles, K
机构
[1] Res Ctr Julich, Inst Med, D-52425 Julich, Germany
[2] Univ Dusseldorf, C&O Vogt Inst Brain Res, D-40001 Dusseldorf, Germany
关键词
quantitative receptor autoradiography; glutamate receptors; gender differences;
D O I
10.1002/cne.10638
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Steroid hormones systematically affect numerous neuronal targets, thus influencing, in a permanent or a transitory manner, the way the brain reacts to external and internal stimuli. The hippocampus is an important brain region for learning and memory and the glutamatergic intrahippocampal pathway plays a major role in performing such functions. We applied quantitative in vitro receptor autoradiography to examine how the in vivo hormone milieu affects the densities of AMPA, kainate, and NMDA receptors in the hippocampus of adult male rats and females in estrus and diestrus. All three examined receptor types presented significant gender-specific differences in their densities. The hippocampus of male rats contains significantly more AMPA, kainate, and NMDA receptors than that of female rats. Female rats in diestrus have significantly higher AMPA receptor densities than female rats in estrus. AMPA changes occurred to the same extent in CA1-3 and in the dentate gyrus. Significant differences in the densities of NMDA receptors were observed in the CA1-3 regions, whereas kainate receptor differences were restricted to the CA1 region. These results further support that steroid hormones, through their modulation of AMPA and NMDA receptors, may be involved in the control of synaptic efficacy and, therefore, influence learning and memory. (C) 2003 Wiley-Liss, Inc.
引用
收藏
页码:468 / 474
页数:7
相关论文
共 69 条
[1]   Different modes of hippocampal plasticity in response to estrogen in young and aged female rats [J].
Adams, MM ;
Shah, RA ;
Janssen, WGM ;
Morrison, JH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (14) :8071-8076
[2]   Neurophysiological and clinical aspects of glucocorticoids and memory: A review [J].
Alderson, AL ;
Novack, TA .
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY, 2002, 24 (03) :335-355
[3]   Estradiol facilitates performance as working memory load increases [J].
Bimonte, HA ;
Denenberg, VH .
PSYCHONEUROENDOCRINOLOGY, 1999, 24 (02) :161-173
[4]   A SYNAPTIC MODEL OF MEMORY - LONG-TERM POTENTIATION IN THE HIPPOCAMPUS [J].
BLISS, TVP ;
COLLINGRIDGE, GL .
NATURE, 1993, 361 (6407) :31-39
[5]   Kainate receptors are involved in synaptic plasticity [J].
Bortolotto, ZA ;
Clarke, VRJ ;
Delany, CM ;
Parry, MC ;
Smolders, I ;
Vignes, M ;
Ho, KH ;
Miu, P ;
Brinton, BT ;
Fantaske, R ;
Ogden, A ;
Gates, M ;
Ornstein, PL ;
Lodge, D ;
Bleakman, D ;
Collingridge, GL .
NATURE, 1999, 402 (6759) :297-301
[6]   Sexual dimorphism of GABA(A) receptor levels in subcortical brain regions of a woodland rodent (Apodemus sylvaticus) [J].
Canonaco, M ;
Tavolaro, R ;
Facciolo, RM ;
Carelli, A ;
Cagnin, M ;
Cristaldi, M .
BRAIN RESEARCH BULLETIN, 1996, 40 (03) :187-194
[7]  
CHAN LU, 2002, MOL PHARM, V61, P1097
[8]   Kainate receptors: subunits, synaptic localization and function [J].
Chittajallu, R ;
Braithwaite, SP ;
Clarke, VRJ ;
Henley, JM .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1999, 20 (01) :26-35
[9]   ADRENAL-HORMONE EFFECTS ON HIPPOCAMPAL EXCITATORY AMINO-ACID BINDING [J].
CLARK, AS ;
COTMAN, CW .
BRAIN RESEARCH, 1992, 585 (1-2) :161-168
[10]   EXCITATORY AMINO-ACID RECEPTORS AND SYNAPTIC PLASTICITY [J].
COLLINGRIDGE, GL ;
SINGER, W .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1990, 11 (07) :290-296