Direct imaging of glymphatic transport using H217O MRI

被引：37
作者：
Alshuhri, Mohammed S. [1 ,2 ]
Gallagher, Lindsay [1 ]
Work, Lorraine M. [3 ]
Holmes, William M. [1 ]
机构：
[1] Univ Glasgow, Coll Med Vet & Life Sci, Inst Neurosci & Psychol, Glasgow, Lanark, Scotland
[2] Prince Sattam bin Abdulaziz Univ, Coll Appl Med Sci, Radiol & Med Imaging Dept, Al Kharj, Saudi Arabia
[3] Univ Glasgow, Coll Med Vet & Life Sci, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland
来源：
JCI INSIGHT | 2021年 / 6卷 / 10期
关键词：
IN-VIVO MEASUREMENT; CEREBROSPINAL-FLUID; MAGNETIC-RESONANCE; BLOOD-FLOW; BRAIN; AQUAPORIN-4; CLEARANCE; DIFFUSION; PATHWAY;
D O I：
10.1172/jci.insight.141159
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The recently proposed glymphatic pathway for solute transport and waste clearance from the brain has been the focus of intense debate. By exploiting an isotopically enriched MRI tracer, (H2O)-O-17, we directly imaged glymphatic water transport in the rat brain in vivo. Our results reveal glymphatic transport that is dramatically faster and more extensive than previously thought and unlikely to be explained by diffusion alone. Moreover, we confirm the critical role of aquaporin-4 channels in glymphatic transport.
引用
收藏
页数：9
相关论文
共 35 条
  • [21] Aquaporin-4-dependent glymphatic solute transport in the rodent brain
    Mestre, Humberto
    Hablitz, Lauren M.
    Xavier, Anna L. R.
    Feng, Weixi
    Zou, Wenyan
    Pu, Tinglin
    Monai, Hiromu
    Murlidharan, Giridhar
    Rivera, Ruth M. Castellanos
    Simon, Matthew J.
    Pike, Martin M.
    Pla, Virginia
    Du, Ting
    Kress, Benjamin T.
    Wang, Xiaowen
    Plog, Benjamin A.
    Thrane, Alexander S.
    Lundgaard, Iben
    Abe, Yoichiro
    Yasui, Masato
    Thomas, John H.
    Xiao, Ming
    Hirase, Hajime
    Asokan, Aravind
    Iliff, Jeffrey J.
    Nedergaard, Maiken
    [J]. ELIFE, 2018, 7
  • [22] Oreskovic D, 2014, FLUIDS BARRIERS CNS, V11, DOI 10.1186/2045-8118-11-16
  • [23] Qaisi A, INVESTIGATION MAGNET
  • [24] Brain-wide glymphatic enhancement and clearance in humans assessed with MRI
    Ringstad, Geir
    Valnes, Lars M.
    Dale, Anders M.
    Pripp, Are H.
    Vatnehol, Svein-Are S.
    Emblem, Kyrre E.
    Mardal, Kent-Andre
    Eide, Per K.
    [J]. JCI INSIGHT, 2018, 3 (13):
  • [25] Distribution of microglia and astrocytes in different regions of the normal adult rat brain
    Savchenko, VL
    Nikonenko, IR
    Skibo, GG
    McKanna, JA
    [J]. NEUROPHYSIOLOGY, 1997, 29 (06) : 343 - 351
  • [26] Mood effects on limbic blood flow correlate with emotional self-rating: A PET study with oxygen-15 labeled water
    Schneider, F
    Gur, RE
    Mozley, LH
    Smith, RJ
    Mozley, PD
    Censits, DM
    Alavi, A
    Gur, RC
    [J]. PSYCHIATRY RESEARCH-NEUROIMAGING, 1995, 61 (04) : 265 - 283
  • [27] CrossTalk opposing view: Going against the flow: interstitial solute transport in brain is diffusive and aquaporin-4 independent
    Smith, Alex J.
    Verkman, Alan S.
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 2019, 597 (17): : 4421 - 4424
  • [28] Smith AJ, 2017, ELIFE, V6, DOI [10.7554/elife.27679, 10.7554/eLife.27679]
  • [29] Ligand-Based Molecular MRI: O-17 JJVCPE Amyloid Imaging in Transgenic Mice
    Suzuki, Kiyotaka
    Igarashi, Hironaka
    Huber, Vincent J.
    Kitaura, Hiroki
    Kwee, Ingrid L.
    Nakada, Tsutomu
    [J]. JOURNAL OF NEUROIMAGING, 2014, 24 (06) : 595 - 598
  • [30] Indirect 17O-magnetic resonance imaging of cerebral blood flow in the rat
    Tailor, DR
    Roy, A
    Regatte, RR
    Charagundla, SR
    McLaughlin, AC
    Leigh, JS
    Reddy, R
    [J]. MAGNETIC RESONANCE IN MEDICINE, 2003, 49 (03) : 479 - 487
1234