Direct imaging of glymphatic transport using H217O MRI

被引：37
作者：
Alshuhri, Mohammed S. [1 ,2 ]
Gallagher, Lindsay [1 ]
Work, Lorraine M. [3 ]
Holmes, William M. [1 ]
机构：
[1] Univ Glasgow, Coll Med Vet & Life Sci, Inst Neurosci & Psychol, Glasgow, Lanark, Scotland
[2] Prince Sattam bin Abdulaziz Univ, Coll Appl Med Sci, Radiol & Med Imaging Dept, Al Kharj, Saudi Arabia
[3] Univ Glasgow, Coll Med Vet & Life Sci, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland
来源：
JCI INSIGHT | 2021年 / 6卷 / 10期
关键词：
IN-VIVO MEASUREMENT; CEREBROSPINAL-FLUID; MAGNETIC-RESONANCE; BLOOD-FLOW; BRAIN; AQUAPORIN-4; CLEARANCE; DIFFUSION; PATHWAY;
D O I：
10.1172/jci.insight.141159
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The recently proposed glymphatic pathway for solute transport and waste clearance from the brain has been the focus of intense debate. By exploiting an isotopically enriched MRI tracer, (H2O)-O-17, we directly imaged glymphatic water transport in the rat brain in vivo. Our results reveal glymphatic transport that is dramatically faster and more extensive than previously thought and unlikely to be explained by diffusion alone. Moreover, we confirm the critical role of aquaporin-4 channels in glymphatic transport.
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页数：9
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