Microbiome, Metabolome and Inflammatory Bowel Disease

被引:132
作者
Ahmed, Ishfaq [1 ]
Roy, Badal C. [1 ]
Khan, Salman A. [2 ,3 ]
Septer, Seth [2 ,3 ]
Umar, Shahid [1 ]
机构
[1] Univ Kansas, Med Ctr, Dept Surg, 3901 Rainbow Blvd,4028 Wahl Hall East, Kansas City, KS 66160 USA
[2] Univ Missouri, Dept Internal Med, Kansas City, MO 64110 USA
[3] Univ Missouri, Dept Pediat, Kansas City, MO 64110 USA
关键词
microbiome; metabolome; metabolites; dysbiosis; inflammation bowel diseases; prebiotics; probiotics; BUTYRATE-PRODUCING BACTERIA; INVASIVE ESCHERICHIA-COLI; CROHNS-DISEASE; ULCERATIVE-COLITIS; GUT MICROBIOTA; ILEAL MUCOSA; INTESTINAL MICROBIOTA; ENTERAL NUTRITION; CLOSTRIDIUM-DIFFICILE; SEROLOGICAL MARKERS;
D O I
10.3390/microorganisms4020020
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Inflammatory Bowel Disease (IBD) is a multifactorial disorder that conceptually occurs as a result of altered immune responses to commensal and/or pathogenic gut microbes in individuals most susceptible to the disease. During Crohn's Disease (CD) or Ulcerative Colitis (UC), two components of the human IBD, distinct stages define the disease onset, severity, progression and remission. Epigenetic, environmental (microbiome, metabolome) and nutritional factors are important in IBD pathogenesis. While the dysbiotic microbiota has been proposed to play a role in disease pathogenesis, the data on IBD and diet are still less convincing. Nonetheless, studies are ongoing to examine the effect of pre/probiotics and/or FODMAP reduced diets on both the gut microbiome and its metabolome in an effort to define the healthy diet in patients with IBD. Knowledge of a unique metabolomic fingerprint in IBD could be useful for diagnosis, treatment and detection of disease pathogenesis.
引用
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页数:19
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