Targeting SARS-CoV-2 Polymerase with New Nucleoside Analogues

被引：10

作者：

Daikopoulou, Vasiliki ^{[1
]}

Apostolou, Panagiotis ^{[1
]}

Mourati, Sofia ^{[1
]}

Vlachou, Ioanna ^{[1
]}

Gougousi, Maria ^{[1
]}

Papasotiriou, Ioannis ^{[2
]}

机构：

[1] Res Genet Canc Ctr SA Ind Area Florina, GR-53100 Florina, Greece

[2] Res Genet Canc Ctr Int GmbH, Baarerstr 95, CH-6301 Zug, Switzerland

来源：

MOLECULES | 2021年 / 26卷 / 11期

关键词：

nucleoside derivatives; COVID-19; quinazoline moiety; QUINAZOLINE DERIVATIVES; REPLICATION; DRUGS;

D O I：

10.3390/molecules26113461

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Despite the fact that COVID-19 vaccines are already available on the market, there have not been any effective FDA-approved drugs to treat this disease. There are several already known drugs that through drug repositioning have shown an inhibitory activity against SARS-CoV-2 RNA-dependent RNA polymerase. These drugs are included in the family of nucleoside analogues. In our efforts, we synthesized a group of new nucleoside analogues, which are modified at the sugar moiety that is replaced by a quinazoline entity. Different nucleobase derivatives are used in order to increase the inhibition. Five new nucleoside analogues were evaluated with in vitro assays for targeting polymerase of SARS-CoV-2.

引用

页数：12

共 43 条

[1] Analysis of SARS-CoV-2 RNA-dependent RNA polymerase as a potential therapeutic drug target using a computational approach [J].

Aftab, Syed Ovais ;

Ghouri, Muhammad Zubair ;

Masood, Muhammad Umer ;

Haider, Zeshan ;

Khan, Zulqurnain ;

Ahmad, Aftab ;

Munawar, Nayla .

JOURNAL OF TRANSLATIONAL MEDICINE, 2020, 18 (01)

[2]

[Anonymous], WHO CORONAVIRUS COVI

[3] Novel Nucleoside Analogues as Effective Antiviral Agents for Zika Virus Infections [J].

Bassetto, Marcella ;

Cima, Cecilia M. ;

Basso, Mattia ;

Salerno, Martina ;

Schwarze, Frank ;

Friese, Daniela ;

Bugert, Joachim J. ;

Brancale, Andrea .

MOLECULES, 2020, 25 (20)

[4]

Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases, LIVERTOX CLIN RES IN

[5] Inhibition of hepatitis C virus RNA replication by 2′-modified nucleoside analogs [J].

Carroll, SS ;

Tomassini, JE ;

Bosserman, M ;

Getty, K ;

Stahlhut, MW ;

Eldrup, AB ;

Bhat, B ;

Hall, D ;

Simcoe, AL ;

LaFemina, R ;

Rutkowski, CA ;

Wolanski, B ;

Yang, ZC ;

Migliaccio, G ;

De Francesco, R ;

Kuo, LC ;

MacCoss, M ;

Olsen, DB .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (14) :11979-11984

[6]

Chien MC, 2020, J PROTEOME RES, V19, P4690, DOI [10.1021/acs.jproteome.0c00392, 10.1101/2020.03.18.997585]

[7] Nucleoside anticancer drugs: the role of nucleoside transporters in resistance to cancer chemotherapy [J].

Damaraju, VL ;

Damaraju, S ;

Young, JD ;

Baldwin, SA ;

Mackey, J ;

Sawyer, MB ;

Cass, CE .

ONCOGENE, 2003, 22 (47) :7524-7536

[8] Approved Antiviral Drugs over the Past 50 Years [J].

De Clercq, Erik ;

Li, Guangdi .

CLINICAL MICROBIOLOGY REVIEWS, 2016, 29 (03) :695-747

[9]

El-Sherbeny MA, 2003, ARZNEIMITTELFORSCH, V53, P206

[10]

Eyer Ludek, 2018, Antiviral Chemistry & Chemotherapy, V26, DOI 10.1177/2040206618761299

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