Cholesterol and fat lowering with hydrophobic polysaccharide derivatives

被引：28

作者：

Copikova, Jana ^{[1
]}

Taubner, Tomas ^{[1
]}

Tuma, Jan ^{[1
]}

Synytsya, Andriy ^{[1
]}

Duskova, Dagmar ^{[2
]}

Marounek, Milan ^{[2
]}

机构：

[1] ICT Prague, Dept Carbohydrate Chem & Technol, Prague 16628 6, Dejvice, Czech Republic

[2] Acad Sci Czech Republ, Inst Anim Physiol & Genet, CR-10400 Prague 10, Uhrineves, Czech Republic

来源：

CARBOHYDRATE POLYMERS | 2015年 / 116卷

关键词：

Hydrophobically modified polysaccharides; Structure; Thermal analysis; Cholate and cholesterol sorption; AMIDATED PECTIN; N-ACYLATION; BILE-ACIDS; CHOLESTYRAMINE; CHITOSAN; OCTADECYLPECTINAMIDE; HOMEOSTASIS; ISOTHERM;

D O I：

10.1016/j.carbpol.2014.05.009

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Hydrophobic derivatives of highly methylated citrus pectin, chitosan and cellulose were prepared and tested as potential cholesterol lowering agents. Elemental analysis and spectroscopic methods confirmed high substitution degree for all of them. Substitution with long alkyl/acyl groups led to significant changes in physical and thermal properties of modified polysaccharides. Sorption of cholate and cholesterol by these polysaccharide-based sorbents was estimated in comparison with the synthetic drug cholestyramine. It was found that modified polysaccharides have high affinity to cholesterol. By contrast, cholestyramine was effective only in cholate sorption. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：207 / 214

页数：8

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