Efficacy and safety of vinorelbine in heavily pretreated recurrent/metastatic head and neck squamous cell carcinoma patients

被引：1

作者：

Barth, Claire ^{[1
]}

Naveau, Louise ^{[1
]}

Touboul, Emmanuel ^{[1
]}

Perie, Sophie ^{[2
]}

Bamogho, Edith ^{[1
]}

Haberer-Guillerm, Sophie ^{[1
]}

Schlienger, Michel ^{[1
]}

St Guily, Jean Lacau ^{[2
]}

Huguet, Florence ^{[1
]}

机构：

[1] Univ Paris 06, Tenon Hosp, HUEP, Dept Radiat Oncol, Paris, France

[2] Univ Paris 06, Tenon Hosp, HUEP, Dept Head & Neck Surg, Paris, France

来源：

ANTI-CANCER DRUGS | 2016年 / 27卷 / 04期

关键词：

vinorelbine; head and neck cancer; chemotherapy; recurrent; metastatic; PLATINUM-BASED CHEMOTHERAPY; PHASE-II TRIAL; METASTATIC HEAD; RECURRENT; CANCER; CARBOPLATIN; PACLITAXEL; CISPLATIN; CETUXIMAB; METHOTREXATE;

D O I：

10.1097/CAD.0000000000000333

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The aim of this study was to evaluate the efficacy and tolerance of vinorelbine as a single agent in the treatment of recurrent/metastatic head and neck squamous cell carcinoma. Patients were treated with oral or intravenous vinorelbine according to the pluridisciplinary tumor board's decision. Efficacy and safety outcomes were analyzed retrospectively. Twenty-three patients were included in the study. Sixteen patients (69%) had received at least two previous lines of chemotherapy. The disease control rate was 19%. The median progression-free survival was 2.6 months and the median overall survival was 3.4 months. The rate of grade 3-4 side effects was low (13%). Only one patient discontinued treatment because of side effects. Vinorelbine seems to be a well-tolerated regimen in heavily pretreated patients. However, this regimen does not seem to be efficient enough to be recommended.

引用

页码：349 / 352

页数：4

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