IKKα at the crossroads of inflammation and metastasis

被引：53
作者：
Affara, Nesrine I.
Coussens, Lisa M.
机构：
[1] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Canc Res Inst, San Francisco, CA 94143 USA
[3] Univ Calif San Francisco, Ctr Comprehens Canc, San Francisco, CA 94143 USA
来源：
CELL | 2007年 / 129卷 / 01期
关键词：
D O I：
10.1016/j.cell.2007.03.029
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The development of solid tumors is regulated by dynamic interactions between evolving neoplastic cells and their microenvironment. Luo et al. (2007) recently demonstrated that tumor-infiltrating immune cells expressing RANKL induce activation and nuclear localization of IKK alpha in prostatic epithelial tumor cells. This leads to repression of maspin, a critical suppressor of metastasis, and thus commits malignant prostatic epithelial cells to a metastatic fate.
引用
收藏
页码：25 / 26
页数：2
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